SMG7 and TNFSF4

		SMG7	TNFSF4
Description		SMG7 nonsense mediated mRNA decay factor	TNF superfamily member 4
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GO Annotations	Cellular Component	Nucleus Telomerase Holoenzyme Complex Cytoplasm Cytosol Intermediate Filament Cytoskeleton	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Protein Binding Telomeric DNA Binding Protein Phosphatase 2A Binding Telomerase RNA Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Regulation Of Dephosphorylation	Positive Regulation Of Cytokine Production Defense Response To Nematode Acute Inflammatory Response Positive Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Cytokine Production Regulation Of Adaptive Immune Response Positive Regulation Of Type 2 Immune Response Positive Regulation Of Immunoglobulin Mediated Immune Response Inflammatory Response Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Virus Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Memory T Cell Activation T-helper 2 Cell Activation Response To Nitrogen Dioxide Positive Regulation Of T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Memory T Cell Differentiation Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Alpha-beta T Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of B Cell Activation Cellular Response To Lipopolysaccharide Cellular Response To Prostaglandin E Stimulus Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Initial pursuit acceleration ( 29064472) Systemic lupus erythematosus ( 27399966 26502338 28714469)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Alopecia areata ( 25337690) Asthma ( 31361310 30929738 34103634 27182965 32296059) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Celiac disease ( 20190752 24999842) Crohn's disease ( 21102463) Diabetic retinopathy ( 21441570) IgA levels ( 28628107) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966 23273568 26663301 26502338 32771030 28714469 19838193 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989) Vein graft stenosis in coronary artery bypass grafting ( 25881214)
Interacting Genes		7 interacting genes: FGFR3 GSK3A GSK3B MDM2 SIRPA SMG5 TNFSF4	10 interacting genes: CERS2 COLGALT2 IL10 LTB4R PACSIN3 SMG7 SOAT1 TNFRSF4 TPR TRAF2
Entrez ID		9887	7292
HPRD ID		10723	04668
Ensembl ID		ENSG00000116698	ENSG00000117586
Uniprot IDs		E9PD50 Q6TV06 Q92540	A0A024R937 P23510
PDB IDs		1YA0	2HEV
Enriched GO Terms of Interacting Partners?
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