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GSK3A and PSMD8
Number of citations of the paper that reports this interaction (PubMedID
30824926
)
2
Data Source:
BioGRID
(two hybrid)
GSK3A
PSMD8
Description
glycogen synthase kinase 3 alpha
proteasome 26S subunit, non-ATPase 8
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Microtubule
Axon
Beta-catenin Destruction Complex
Neuronal Cell Body
Apical Dendrite
Postsynapse
Proximal Dendrite
Proteasome Complex
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle
Proteasome Regulatory Particle, Lid Subcomplex
Proteasome Accessory Complex
Molecular Function
Protein Serine/threonine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Protein Kinase A Catalytic Subunit Binding
Tau Protein Binding
Tau-protein Kinase Activity
Protein Serine Kinase Activity
Protein Binding
Biological Process
Regulation Of Systemic Arterial Blood Pressure
Cardiac Left Ventricle Morphogenesis
Glycogen Metabolic Process
Regulation Of Gene Expression By Genetic Imprinting
Protein Phosphorylation
Signal Transduction
Dopamine Receptor Signaling Pathway
Nervous System Development
Aging
Insulin Receptor Signaling Pathway
Positive Regulation Of Autophagy
Positive Regulation Of Gene Expression
Positive Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of UDP-glucose Catabolic Process
Regulation Of Neuron Projection Development
Wnt Signaling Pathway
Cell Migration
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of TOR Signaling
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Insulin Stimulus
Positive Regulation Of Peptidyl-serine Phosphorylation
Cellular Response To Interleukin-3
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Neuron Apoptotic Process
Hypermethylation Of CpG Island
Negative Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Heart Contraction
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Glucose Import
Negative Regulation Of Insulin Receptor Signaling Pathway
Excitatory Postsynaptic Potential
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Cellular Response To Lithium Ion
Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Amyloid-beta Formation
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Glycogen Synthase Activity, Transferring Glucose-1-phosphate
Negative Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of Dendrite Development
Negative Regulation Of Glycogen (starch) Synthase Activity
Positive Regulation Of Glycogen (starch) Synthase Activity
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways
AKT phosphorylates targets in the cytosol
XBP1(S) activates chaperone genes
Constitutive Signaling by AKT1 E17K in Cancer
Suppression of apoptosis
Maturation of nucleoprotein
Maturation of nucleoprotein
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
ROS sensing by NFE2L2
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Fostamatinib
Diseases
GWAS
Meat-related diet (
32066663
)
HDL cholesterol levels (
32203549
)
Interacting Genes
80 interacting genes:
AKAP11
AKT1
ALKBH3
AP3D1
AURKAIP1
AXIN2
BCCIP
BCL2L1
BCL3
BICD1
C11orf98
CCDC174
CHTOP
CNTROB
CREB1
CREM
DCAF8
DCP1B
DDI1
DEAF1
DNAJB1
DRC1
EBNA1BP2
EIF2B5
FAM193B
FBXO42
GLI3
GOLGA6C
GSKIP
H2AZ2
HMBS
HMGN1
HNRNPM
HSF1
HSP90AA1
HSP90AB1
LDHA
LRP6
LRRC37A2
LRSAM1
MAEA
MAPT
MCL1
MPHOSPH9
MTCH1
MYC
MYL12A
NBR1
OGT
PRKACA
PRKCA
PRKCB
PRKCD
PRKCG
PRKCH
PRKCZ
PRKD3
PRKDC
PSMD8
PTMA
PXN
RICTOR
RPL15
RPL19
RPL29
RPS15
RPS19
RUNX1
SBNO1
SGK1
SGK3
SMARCA5
SMG7
SPG21
STAT2
SUGP2
TTC16
UBTF
VCPIP1
YWHAG
19 interacting genes:
CCDC92
ELF4
GLP1R
GSK3A
GSK3B
MTNR1B
PLSCR2
PRDX6
PSG11
PSG5
PVR
RPS19
SHC3
SMAD2
SMAD9
SNRPD2
UBC
UCHL5
XRCC1
Entrez ID
2931
5714
HPRD ID
06002
10171
Ensembl ID
ENSG00000105723
ENSG00000099341
Uniprot IDs
A0A024R0L5
P49840
P48556
V9HW09
PDB IDs
2DFM
5GJQ
5GJR
5L4K
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHS
6MSB
6MSD
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
Enriched GO Terms of Interacting Partners
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