PCLAF and DNMT1

Number of citations of the paper that reports this interaction (PubMedID 21628590)
47

Data Source:
BioGRID (unspecified method, affinity chromatography technology)

		PCLAF	DNMT1
Description		PCNA clamp associated factor	DNA methyltransferase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Centrosome Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Replication Fork Pericentric Heterochromatin
	Molecular Function	Chromatin Binding Protein Binding	DNA Binding RNA Binding DNA (cytosine-5-)-methyltransferase Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding DNA-methyltransferase Activity Promoter-specific Chromatin Binding
	Biological Process	DNA Replication Cellular Response To DNA Damage Stimulus Centrosome Cycle Response To UV Translesion Synthesis Regulation Of Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Organization Ras Protein Signal Transduction Maintenance Of DNA Methylation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Gene Silencing DNA Methylation Involved In Embryo Development Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine Positive Regulation Of DNA Methylation-dependent Heterochromatin Assembly Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching
Pathways		Termination of translesion DNA synthesis	PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation Defective pyroptosis
Drugs			Procaine Azacitidine Procainamide Flucytosine Decitabine Palifosfamide Epigallocatechin gallate
Diseases
GWAS			Birth weight ( 31043758) Immature fraction of reticulocytes ( 27863252) Narcolepsy ( 24204295) Offspring birth weight ( 31043758) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		4 interacting genes: DNMT1 PCNA TERF1 UHRF1	51 interacting genes: AKT1 BAZ2A BRAP CBX1 CSNK2B DAXX DCAF5 DMAP1 DNASE2 DNM2 DNMT3A DNMT3B DYNLL1 E2F6 EED EEF1A1 ELAVL3 ENSA EZH2 GSK3B H2BC3 H3-4 HDAC1 HDAC2 HELLS HMGB1 L3MBTL3 LASP1 MCRIP1 MECP2 NGRN NRIP1 PCLAF PCNA PEBP1 PHC2 PICK1 PRKAA2 RB1 RGS6 RPS6KA6 RUNX1 RUNX1T1 SETD7 SUMO2 SUV39H1 TRIM27 TRIM3 TSG101 UBB YWHAQ
Entrez ID		9768	1786
HPRD ID		13778	00532
Ensembl ID		ENSG00000166803	ENSG00000130816
Uniprot IDs		Q15004	I6L9H2 P26358 Q59FP7
PDB IDs		4D2G 6EHT 6GWS 6IIW	3EPZ 3PTA 3SWR 4WXX 4YOC 4Z96 4Z97 5WVO 5YDR 6K3A
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?