DNMT1 and HELLS

Number of citations of the paper that reports this interaction (PubMedID 17967891)
68

Data Source:
BioGRID (pull down)

		DNMT1	HELLS
Description		DNA methyltransferase 1	helicase, lymphoid specific
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Pericentric Heterochromatin	Chromosome, Centromeric Region Nucleus Pericentric Heterochromatin
	Molecular Function	DNA Binding RNA Binding DNA (cytosine-5-)-methyltransferase Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding DNA-methyltransferase Activity Promoter-specific Chromatin Binding	Chromatin Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP-dependent Chromatin Remodeler Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Organization Ras Protein Signal Transduction Maintenance Of DNA Methylation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Gene Silencing DNA Methylation Involved In Embryo Development Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine Positive Regulation Of DNA Methylation-dependent Heterochromatin Assembly Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching	Urogenital System Development DNA Methylation DNA Methylation-dependent Heterochromatin Assembly Cell Cycle Multicellular Organism Development Maintenance Of DNA Methylation Pericentric Heterochromatin Assembly Lymphocyte Proliferation Cell Division Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation Defective pyroptosis
Drugs		Procaine Azacitidine Procainamide Flucytosine Decitabine Palifosfamide Epigallocatechin gallate
Diseases
GWAS		Birth weight ( 31043758) Immature fraction of reticulocytes ( 27863252) Narcolepsy ( 24204295) Offspring birth weight ( 31043758) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Red cell distribution width ( 32888494) Response to (pegylated) interferon in chronic hepatitis B ( 30715261) Serum alkaline phosphatase levels ( 33547301) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		51 interacting genes: AKT1 BAZ2A BRAP CBX1 CSNK2B DAXX DCAF5 DMAP1 DNASE2 DNM2 DNMT3A DNMT3B DYNLL1 E2F6 EED EEF1A1 ELAVL3 ENSA EZH2 GSK3B H2BC3 H3-4 HDAC1 HDAC2 HELLS HMGB1 L3MBTL3 LASP1 MCRIP1 MECP2 NGRN NRIP1 PCLAF PCNA PEBP1 PHC2 PICK1 PRKAA2 RB1 RGS6 RPS6KA6 RUNX1 RUNX1T1 SETD7 SUMO2 SUV39H1 TRIM27 TRIM3 TSG101 UBB YWHAQ	10 interacting genes: APP DNMT1 DNMT3B E2F3 GPAT4-AS1 GTSF1L H1-2 HDAC1 MEOX2 SERTAD2
Entrez ID		1786	3070
HPRD ID		00532	07232
Ensembl ID		ENSG00000130816	ENSG00000119969
Uniprot IDs		I6L9H2 P26358 Q59FP7	A0A087WSW7 A0A0B4J1V9 F6XU50 Q0VGL2 Q76H82 Q9NRZ9
PDB IDs		3EPZ 3PTA 3SWR 4WXX 4YOC 4Z96 4Z97 5WVO 5YDR 6K3A
Enriched GO Terms of Interacting Partners?
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