DNMT1 and TRIM3

Number of citations of the paper that reports this interaction (PubMedID 21653829)
98

Data Source:
BioGRID (two hybrid)

		DNMT1	TRIM3
Description		DNA methyltransferase 1	tripartite motif containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Pericentric Heterochromatin	Cytoplasm Early Endosome Golgi Apparatus Dendrite
	Molecular Function	DNA Binding RNA Binding DNA (cytosine-5-)-methyltransferase Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding DNA-methyltransferase Activity Promoter-specific Chromatin Binding	Protein Binding Protein C-terminus Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Organization Ras Protein Signal Transduction Maintenance Of DNA Methylation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Gene Silencing DNA Methylation Involved In Embryo Development Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine Positive Regulation Of DNA Methylation-dependent Heterochromatin Assembly Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching	Protein Polyubiquitination Nervous System Development Protein Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation Defective pyroptosis	Interferon gamma signaling
Drugs		Procaine Azacitidine Procainamide Flucytosine Decitabine Palifosfamide Epigallocatechin gallate
Diseases
GWAS		Birth weight ( 31043758) Immature fraction of reticulocytes ( 27863252) Narcolepsy ( 24204295) Offspring birth weight ( 31043758) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Malaria ( 31844061)
Interacting Genes		51 interacting genes: AKT1 BAZ2A BRAP CBX1 CSNK2B DAXX DCAF5 DMAP1 DNASE2 DNM2 DNMT3A DNMT3B DYNLL1 E2F6 EED EEF1A1 ELAVL3 ENSA EZH2 GSK3B H2BC3 H3-4 HDAC1 HDAC2 HELLS HMGB1 L3MBTL3 LASP1 MCRIP1 MECP2 NGRN NRIP1 PCLAF PCNA PEBP1 PHC2 PICK1 PRKAA2 RB1 RGS6 RPS6KA6 RUNX1 RUNX1T1 SETD7 SUMO2 SUV39H1 TRIM27 TRIM3 TSG101 UBB YWHAQ	34 interacting genes: ACTN4 ASL CDKN1A CEP70 CSNK1D CSNK1E DNMT1 FXR1 FXR2 KCTD7 KIF21B LNX1 LRRC8E MYO5A MYO5B ROPN1 TEAD1 TEAD2 TNFAIP3 TPTEP2-CSNK1E TRIM2 TRIM21 TSC1 UBE2D1 UBE2D2 UBE2D4 UBE2E1 UBE2E2 UBE2G2 UBE2I UBE2K UBE2U UBE2Z USP32
Entrez ID		1786	10612
HPRD ID		00532	05690
Ensembl ID		ENSG00000130816	ENSG00000110171
Uniprot IDs		I6L9H2 P26358 Q59FP7	B7Z5Y8 O75382
PDB IDs		3EPZ 3PTA 3SWR 4WXX 4YOC 4Z96 4Z97 5WVO 5YDR 6K3A
Enriched GO Terms of Interacting Partners?
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