SLK and PDZK1

Number of citations of the paper that reports this interaction (PubMedID 14531806)
46

Data Source:
BioGRID (two hybrid, pull down)

		SLK	PDZK1
Description		STE20 like kinase	PDZ domain containing 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cell Leading Edge Perinuclear Region Of Cytoplasm Extracellular Exosome	Plasma Membrane Brush Border Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Protein Serine Kinase Activity	Scavenger Receptor Binding Protein Binding PDZ Domain Binding Protein-membrane Adaptor Activity Protein-containing Complex Binding
	Biological Process	Apoptotic Process Regulation Of Cell Migration Cytoplasmic Microtubule Organization Regulation Of Apoptotic Process Protein Autophosphorylation Regulation Of Focal Adhesion Assembly	Carnitine Transport Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Anion Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Protein Localization To Membrane Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs		K-00546 2-[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]iminocyclohexa-2,5-dien-1-yl]acetonitrile Fostamatinib
Diseases
GWAS		Diastolic blood pressure ( 29403010) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Pulse pressure ( 30487518) Systolic blood pressure ( 30487518) Uterine fibroids ( 21460842 31649266)	Contrast sensitivity ( 24152035) Gout ( 33832965 32238385) Serum uric acid levels ( 30993211) Urate levels ( 31985003 20884846 31578528 23263486) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597)
Interacting Genes		3 interacting genes: CASP3 CLSTN1 PDZK1	31 interacting genes: ABCA1 ABCC2 ABCC4 ACE2 AKAP10 APP CFTR CLCN3 CRHR1 FARP2 GFAP PDZK1IP1 PEX5 RPS6KA1 SCARB1 SLC13A1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A1 SLC9A3 SLC9A3R1 SLC9A3R2 SLCO1A2 SLK SSTR5 UBE2I
Entrez ID		9748	5174
HPRD ID		11585	04829
Ensembl ID		ENSG00000065613	ENSG00000174827
Uniprot IDs		Q9H2G2	Q5T2W1
PDB IDs		2J51 2JFL 2JFM 2UV2 4USF 6HVD	2EEI 2EEJ 2VSP 3TMH 4Q2P 6EZI
Enriched GO Terms of Interacting Partners?
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