SLK and CLSTN1

Number of citations of the paper that reports this interaction (PubMedID 12421765)
41

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SLK	CLSTN1
Description		STE20 like kinase	calsyntenin 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cell Leading Edge Perinuclear Region Of Cytoplasm Extracellular Exosome	Golgi Membrane Extracellular Region Nucleus Endoplasmic Reticulum Membrane Cell Surface Postsynaptic Membrane Postsynaptic Endosome Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Density Membrane Integral Component Of Spine Apparatus Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Protein Serine Kinase Activity	Amyloid-beta Binding Calcium Ion Binding Protein Binding Kinesin Binding X11-like Protein Binding
	Biological Process	Apoptotic Process Regulation Of Cell Migration Cytoplasmic Microtubule Organization Regulation Of Apoptotic Process Protein Autophosphorylation Regulation Of Focal Adhesion Assembly	Regulation Of Cell Growth Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Positive Regulation Of Synaptic Transmission Positive Regulation Of Synapse Assembly Regulation Of Synapse Maturation Neurotransmitter Receptor Transport To Postsynaptic Membrane Vesicle-mediated Transport In Synapse
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs		K-00546 2-[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]iminocyclohexa-2,5-dien-1-yl]acetonitrile Fostamatinib
Diseases
GWAS		Diastolic blood pressure ( 29403010) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Pulse pressure ( 30487518) Systolic blood pressure ( 30487518) Uterine fibroids ( 21460842 31649266)
Interacting Genes		3 interacting genes: CASP3 CLSTN1 PDZK1	14 interacting genes: APBA2 APBB1 BAHCC1 COL17A1 KIF2A KLC1 KLC2 MCM3AP MDM2 PRNP SETDB1 SLK TOPBP1 TRIP12
Entrez ID		9748	22883
HPRD ID		11585	10837
Ensembl ID		ENSG00000065613	ENSG00000171603
Uniprot IDs		Q9H2G2	B4E3Q1 O94985
PDB IDs		2J51 2JFL 2JFM 2UV2 4USF 6HVD
Enriched GO Terms of Interacting Partners?
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