EIF5B and ECT2

Number of citations of the paper that reports this interaction (PubMedID 22990118)
49

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		EIF5B	ECT2
Description		eukaryotic translation initiation factor 5B	epithelial cell transforming 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Cell-cell Junction Bicellular Tight Junction Cell Cortex Nuclear Body Midbody Cleavage Furrow Mitotic Spindle Centralspindlin Complex
	Molecular Function	RNA Binding Translation Initiation Factor Activity GTPase Activity Protein Binding GTP Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity
	Biological Process	Translational Initiation Regulation Of Translational Initiation	Mitotic Cytokinesis Cell Morphogenesis Nervous System Development Protein Transport Cell Differentiation Activation Of Protein Kinase Activity Positive Regulation Of Cytokinesis Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of GTPase Activity Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Bicellular Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Activation Of GTPase Activity Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly
Pathways		GTP hydrolysis and joining of the 60S ribosomal subunit	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)	Obesity-related traits ( 23251661) Red cell distribution width ( 32888494)
Interacting Genes		11 interacting genes: BRCA1 CBL CDC42 CSNK2A1 ECT2 EIF1AX ETS1 PAXIP1 SIRPA TFCP2 ZBTB3	39 interacting genes: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 CSTB EIF4A2 EIF5B ELOC ERAL1 F2RL2 FANCM GGN ILVBL KLHL20 LAMTOR5 MBD1 MT-CO2 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 SRPK2 THAP11 UBB USP7 VDAC2
Entrez ID		9669	1894
HPRD ID		07304	11860
Ensembl ID		ENSG00000158417	ENSG00000114346
Uniprot IDs		O60841 Q8N5A0	Q9H8V3
PDB IDs			3L46 4N40 6L30
Enriched GO Terms of Interacting Partners?
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