ECT2 and C2orf42

Number of citations of the paper that reports this interaction (PubMedID 22990118)
49

Data Source:
BioGRID (two hybrid)

		ECT2	C2orf42
Description		epithelial cell transforming 2	chromosome 2 open reading frame 42
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cell-cell Junction Bicellular Tight Junction Cell Cortex Nuclear Body Midbody Cleavage Furrow Mitotic Spindle Centralspindlin Complex	Nucleus Nucleoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Mitotic Cytokinesis Cell Morphogenesis Nervous System Development Protein Transport Cell Differentiation Activation Of Protein Kinase Activity Positive Regulation Of Cytokinesis Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of GTPase Activity Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Bicellular Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Activation Of GTPase Activity Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Red cell distribution width ( 32888494)	Acne (severe) ( 24927181) Male-pattern baldness ( 28196072) Mean spheric corpuscular volume ( 32888494) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) Red blood cell count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		39 interacting genes: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 CSTB EIF4A2 EIF5B ELOC ERAL1 F2RL2 FANCM GGN ILVBL KLHL20 LAMTOR5 MBD1 MT-CO2 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 SRPK2 THAP11 UBB USP7 VDAC2	8 interacting genes: ALAS1 BMP10 ECT2 HOMEZ PAXIP1 PPP1R13B PRKAB2 TLX3
Entrez ID		1894	54980
HPRD ID		11860	07927
Ensembl ID		ENSG00000114346	ENSG00000115998
Uniprot IDs		Q9H8V3	Q9NWW7
PDB IDs		3L46 4N40 6L30
Enriched GO Terms of Interacting Partners?
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