CD59 and C8A

Number of citations of the paper that reports this interaction (PubMedID 7544344)
12

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		CD59	C8A
Description		CD59 molecule (CD59 blood group)	complement C8 alpha chain
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Anchored Component Of External Side Of Plasma Membrane Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane	Extracellular Region Membrane Attack Complex Extracellular Space Membrane Extracellular Exosome Blood Microparticle
	Molecular Function	Complement Binding Protein Binding	Complement Binding Protein Binding Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Activation Of Membrane Attack Complex Cell Surface Receptor Signaling Pathway Blood Coagulation Regulation Of Complement Activation Regulation Of Complement-dependent Cytotoxicity	Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cytolysis
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER Neutrophil degranulation COPI-mediated anterograde transport Regulation of Complement cascade	Terminal pathway of complement Regulation of Complement cascade
Drugs			Zinc Zinc acetate
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Body size at age 10 ( 32376654) Chronotype ( 30696823) Fruit consumption ( 32066663) Morning person ( 30696823)	Blood protein levels ( 28240269)
Interacting Genes		19 interacting genes: BDNF C8A C9 CCR2 CD2 CD8A CD9 CHRM4 EGFR FAM209A GNAI3 NAT8 NCR1 NCR3 SLC13A1 SLC6A8 SMAD4 SRC WFS1	9 interacting genes: C8B C8G C9 CD59 GOLT1A GPR152 MMGT1 SLC10A1 SLC7A1
Entrez ID		966	731
HPRD ID		00117	00409
Ensembl ID		ENSG00000085063	ENSG00000157131
Uniprot IDs		P13987 Q6FHM9	P07357
PDB IDs		1CDQ 1CDR 1CDS 1ERG 1ERH 2J8B 2OFS 2UWR 2UX2 4BIK 5IMT 5IMY 6ZD0	2QOS 2QQH 2RD7 3OJY 6H03 6H04
Enriched GO Terms of Interacting Partners?
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