RGS6 and DNMT1

Number of citations of the paper that reports this interaction (PubMedID 14734556)
24

Data Source:
BioGRID (pull down)

		RGS6	DNMT1
Description		regulator of G protein signaling 6	DNA methyltransferase 1
Image
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Extrinsic Component Of Membrane	Nucleus Nucleoplasm Replication Fork Pericentric Heterochromatin
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding	DNA Binding RNA Binding DNA (cytosine-5-)-methyltransferase Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding DNA-methyltransferase Activity Promoter-specific Chromatin Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of GTPase Activity	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Organization Ras Protein Signal Transduction Maintenance Of DNA Methylation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Gene Silencing DNA Methylation Involved In Embryo Development Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine Positive Regulation Of DNA Methylation-dependent Heterochromatin Assembly Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching
Pathways		G alpha (i) signalling events G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation Defective pyroptosis
Drugs			Procaine Azacitidine Procainamide Flucytosine Decitabine Palifosfamide Epigallocatechin gallate
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) antipsychotic drug dosage in schizophrenia or schizoaffective disorder ( 26821981) Aspartate aminotransferase levels ( 33547301) Autism spectrum disorder or schizophrenia ( 28540026) Bone mineral density (hip) ( 30172743) C-reactive protein levels ( 33339817 30388399 21300955) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cutaneous psoriasis ( 26626624) Economic and political preferences (environmentalism) ( 22566634) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) General risk tolerance (MTAG) ( 30643258) Heart rate ( 28610988) Heart rate increase in response to exercise ( 29497042) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Heart rate variability traits (RMSSD) ( 28613276) Heart rate variability traits (SDNN) ( 28613276) Intracranial aneurysm ( 29531279) Liver enzyme levels (alkaline phosphatase) ( 33972514) Neuroticism ( 29255261) Night sleep phenotypes ( 27126917) Obesity (extreme) ( 21935397) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma anti-thyroglobulin levels ( 29678681) Resting heart rate ( 29769521 27798624) Schizophrenia ( 28991256 25056061 29483656 30285260) Serum alkaline phosphatase levels ( 33547301) Small cell lung carcinoma ( 28604730) Smoking cessation ( 20811658) Systolic blood pressure ( 30224653 30578418) Transverse temporal cortex volume ( 31530798) Yang-deficiency constitution ( 25533513)	Birth weight ( 31043758) Immature fraction of reticulocytes ( 27863252) Narcolepsy ( 24204295) Offspring birth weight ( 31043758) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: AREL1 DMAP1 DNMT1 GNB5 STMN2 TMED10	51 interacting genes: AKT1 BAZ2A BRAP CBX1 CSNK2B DAXX DCAF5 DMAP1 DNASE2 DNM2 DNMT3A DNMT3B DYNLL1 E2F6 EED EEF1A1 ELAVL3 ENSA EZH2 GSK3B H2BC3 H3-4 HDAC1 HDAC2 HELLS HMGB1 L3MBTL3 LASP1 MCRIP1 MECP2 NGRN NRIP1 PCLAF PCNA PEBP1 PHC2 PICK1 PRKAA2 RB1 RGS6 RPS6KA6 RUNX1 RUNX1T1 SETD7 SUMO2 SUV39H1 TRIM27 TRIM3 TSG101 UBB YWHAQ
Entrez ID		9628	1786
HPRD ID		04871	00532
Ensembl ID		ENSG00000182732	ENSG00000130816
Uniprot IDs		B7Z2A0 B7Z2N1 P49758 Q2M3K2	I6L9H2 P26358 Q59FP7
PDB IDs		2ES0	3EPZ 3PTA 3SWR 4WXX 4YOC 4Z96 4Z97 5WVO 5YDR 6K3A
Enriched GO Terms of Interacting Partners?
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