MED21 and TRIM72

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MED21	TRIM72
Description		mediator complex subunit 21	tripartite motif containing 72
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Mediator Complex	Cytoplasm Cytoplasmic Vesicle Membrane Sarcolemma
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Ubiquitin Protein Ligase Activity	Phosphatidylserine Binding Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Blastocyst Development Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Stem Cell Population Maintenance RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II	Plasma Membrane Repair Muscle System Process Exocytosis Muscle Organ Development Negative Regulation Of Myotube Differentiation Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Protein Homooligomerization
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	Smooth Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases
GWAS		Dimensional psychopathology (Social) ( 29496196)
Interacting Genes		30 interacting genes: BLOC1S6 BORCS6 BRCA1 BTF3 CDK8 CDK9 ELOA ESR1 ESR2 HGS HNF4A HTT MAGEA6 MAGEB4 MED29 MIEF1 PCBD2 POLR2A SKP1 SSC5D TARBP2 TFG THRA THRB TP53 TRIM27 TRIM72 VAV2 ZNF655 ZSCAN1	15 interacting genes: ABI2 C1orf216 INSR IRS1 MED21 MZT1 NMI PPP3CA SMARCD1 TCF12 TRIM32 UBE2I UBE2N VSIG4 ZNF655
Entrez ID		9412	493829
HPRD ID		09156	17412
Ensembl ID		ENSG00000152944	ENSG00000177238
Uniprot IDs		A0A024RAW0 Q13503	Q6ZMU5
PDB IDs			3KB5
Enriched GO Terms of Interacting Partners?
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