LHX2 and CITED2

Number of citations of the paper that reports this interaction (PubMedID 10593900)
37

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		LHX2	CITED2
Description		LIM homeobox 2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Nucleoplasm Protein-containing Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Metal Ion Binding	Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Histone Acetyltransferase Binding SMAD Binding LBD Domain Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Neural Tube Closure Hair Follicle Development Regulation Of Transcription By RNA Polymerase II Axon Guidance Mesoderm Development Dorsal/ventral Pattern Formation Olfactory Bulb Development Telencephalon Regionalization Cerebral Cortex Development Neuron Differentiation Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Axon Extension Negative Regulation Of Neurogenesis Retina Development In Camera-type Eye Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Transcription Regulatory Region DNA Binding	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Response To Hypoxia Trophectodermal Cell Differentiation Neural Tube Closure Liver Development Embryonic Placenta Development Heart Looping Lens Morphogenesis In Camera-type Eye Hematopoietic Progenitor Cell Differentiation Outflow Tract Morphogenesis Regulation Of Animal Organ Formation Endocardial Cushion Development Transforming Growth Factor Beta Receptor Signaling Pathway Determination Of Left/right Symmetry Central Nervous System Development Peripheral Nervous System Development Heart Development Sex Determination Cell Aging Cell Population Proliferation Male Gonad Development Response To Mechanical Stimulus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cranial Nerve Morphogenesis Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Granulocyte Differentiation Response To Fluid Shear Stress Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Adrenal Cortex Formation Skeletal Muscle Cell Differentiation Negative Regulation Of Apoptotic Process Response To Estrogen Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Decidualization Spleen Development Thymus Development Embryonic Camera-type Eye Morphogenesis Erythrocyte Development Negative Regulation Of Cardiac Muscle Cell Proliferation Embryonic Process Involved In Female Pregnancy Bone Morphogenesis Ventricular Septum Morphogenesis Embryonic Heart Tube Left/right Pattern Formation Left/right Pattern Formation Pulmonary Artery Morphogenesis Cardiac Neural Crest Cell Development Involved In Heart Development Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Left/right Axis Specification Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Positive Regulation Of Male Gonad Development
Pathways		Regulation of expression of SLITs and ROBOs	Regulation of gene expression by Hypoxia-inducible Factor TFAP2 (AP-2) family regulates transcription of other transcription factors Activation of the TFAP2 (AP-2) family of transcription factors FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Depression ( 29700475) Hair color ( 29662168) Mercury levels ( 26025379) Post-traumatic stress disorder ( 25456346) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Waist circumference ( 23966867)	Alanine aminotransferase levels ( 33547301) Albumin-globulin ratio ( 29403010) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Blood trace element (Se levels) ( 23720494) Caudate volume in trauma-exposed individuals ( 29187748) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 30224653) Glycated hemoglobin levels ( 28898252) HDL cholesterol ( 24097068 20686565) HDL cholesterol levels ( 32203549 28334899) IgA levels ( 28628107) Mean corpuscular hemoglobin ( 23263863 28453575 20139978 28017375 19862010) Mean corpuscular volume ( 23263863 32888494 28453575 20139978 28017375 19862010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Non-albumin protein levels ( 29403010) Obesity-related traits ( 23251661) Red blood cell traits ( 23222517) Systolic blood pressure ( 30224653) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Triglyceride levels ( 32203549) Triglycerides ( 25961943) Urate levels in lean individuals ( 25811787)
Interacting Genes		29 interacting genes: ANKS1A ARHGAP32 BEND2 CITED2 DNMT3L ENG FLYWCH1 HOMER3 HOXC8 KHK LDB1 LGALSL LNX1 LONRF1 MORF4L1 MORN3 MSX1 OSMR PAX6 POU4F2 PPIL1 RLIM TCEANC TCP11L1 TLK1 TRAPPC2L UBTFL1 ZFP42 ZNF511	11 interacting genes: CREBBP EP300 FBXL5 HIF1A LHX2 LHX3 MAPK1 TBP TFAP2A TFAP2B TFAP2C
Entrez ID		9355	10370
HPRD ID		04786	04245
Ensembl ID		ENSG00000106689	ENSG00000164442
Uniprot IDs		B3KNJ5 P50458	A0A0A0MTM3 D9ZGF1 Q99967
PDB IDs			1P4Q 1R8U
Enriched GO Terms of Interacting Partners?
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