CITED2 and FBXL5

Number of citations of the paper that reports this interaction (PubMedID 25956243)
12

Data Source:
BioGRID (two hybrid, pull down, protein complementation assay)

		CITED2	FBXL5
Description		Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2	F-box and leucine rich repeat protein 5
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Protein-containing Complex	Ubiquitin Ligase Complex Cytosol SCF Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Histone Acetyltransferase Binding SMAD Binding LBD Domain Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Ubiquitin-protein Transferase Activity Iron Ion Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Response To Hypoxia Trophectodermal Cell Differentiation Neural Tube Closure Liver Development Embryonic Placenta Development Heart Looping Lens Morphogenesis In Camera-type Eye Hematopoietic Progenitor Cell Differentiation Outflow Tract Morphogenesis Regulation Of Animal Organ Formation Endocardial Cushion Development Transforming Growth Factor Beta Receptor Signaling Pathway Determination Of Left/right Symmetry Central Nervous System Development Peripheral Nervous System Development Heart Development Sex Determination Cell Aging Cell Population Proliferation Male Gonad Development Response To Mechanical Stimulus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cranial Nerve Morphogenesis Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Granulocyte Differentiation Response To Fluid Shear Stress Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Adrenal Cortex Formation Skeletal Muscle Cell Differentiation Negative Regulation Of Apoptotic Process Response To Estrogen Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Decidualization Spleen Development Thymus Development Embryonic Camera-type Eye Morphogenesis Erythrocyte Development Negative Regulation Of Cardiac Muscle Cell Proliferation Embryonic Process Involved In Female Pregnancy Bone Morphogenesis Ventricular Septum Morphogenesis Embryonic Heart Tube Left/right Pattern Formation Left/right Pattern Formation Pulmonary Artery Morphogenesis Cardiac Neural Crest Cell Development Involved In Heart Development Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Left/right Axis Specification Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Positive Regulation Of Male Gonad Development	Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Iron Ion Homeostasis Positive Regulation Of Cellular Protein Catabolic Process
Pathways		Regulation of gene expression by Hypoxia-inducible Factor TFAP2 (AP-2) family regulates transcription of other transcription factors Activation of the TFAP2 (AP-2) family of transcription factors FOXO-mediated transcription of cell death genes	Association of TriC/CCT with target proteins during biosynthesis Neddylation Iron uptake and transport Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Albumin-globulin ratio ( 29403010) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Blood trace element (Se levels) ( 23720494) Caudate volume in trauma-exposed individuals ( 29187748) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 30224653) Glycated hemoglobin levels ( 28898252) HDL cholesterol ( 24097068 20686565) HDL cholesterol levels ( 32203549 28334899) IgA levels ( 28628107) Mean corpuscular hemoglobin ( 23263863 28453575 20139978 28017375 19862010) Mean corpuscular volume ( 23263863 32888494 28453575 20139978 28017375 19862010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Non-albumin protein levels ( 29403010) Obesity-related traits ( 23251661) Red blood cell traits ( 23222517) Systolic blood pressure ( 30224653) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Triglyceride levels ( 32203549) Triglycerides ( 25961943) Urate levels in lean individuals ( 25811787)	Blood protein levels ( 28240269) Estimated glomerular filtration rate in non-diabetics ( 31451708) Red blood cell count ( 32888494)
Interacting Genes		11 interacting genes: CREBBP EP300 FBXL5 HIF1A LHX2 LHX3 MAPK1 TBP TFAP2A TFAP2B TFAP2C	10 interacting genes: CITED2 CSNK2B DCTN1 EP300 LINC00839 NABP2 ORC4 PLK1 SKP1 SNCA
Entrez ID		10370	26234
HPRD ID		04245	05739
Ensembl ID		ENSG00000164442	ENSG00000118564
Uniprot IDs		A0A0A0MTM3 D9ZGF1 Q99967	Q9UKA1
PDB IDs		1P4Q 1R8U	3U9J 3U9M 3V5X 3V5Y 3V5Z 6VCD
Enriched GO Terms of Interacting Partners?
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