TRIP11 and PSMC5

Number of citations of the paper that reports this interaction (PubMedID 8603043)
3

Data Source:
BioGRID (two hybrid)

		TRIP11	PSMC5
Description		thyroid hormone receptor interactor 11	proteasome 26S subunit, ATPase 5
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Inner Acrosomal Membrane Outer Acrosomal Membrane Nucleoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Cytoskeleton Nuclear Speck Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle, Base Subcomplex Membrane Inclusion Body Proteasome Accessory Complex Cytoplasmic Vesicle Extracellular Exosome Blood Microparticle
	Molecular Function	Transcription Coactivator Activity Protein Binding Small GTPase Binding	Protein Binding ATP Binding Transcription Factor Binding Thyrotropin-releasing Hormone Receptor Binding Proteasome-activating Activity General Transcription Initiation Factor Binding DNA-binding Transcription Factor Binding
	Biological Process	Ventricular Septum Development Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Transcription By RNA Polymerase II Protein Glycosylation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Positive Regulation Of Transcription, DNA-templated Cartilage Development Inner Ear Receptor Cell Stereocilium Organization Golgi Ribbon Formation Vesicle Tethering To Golgi	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Programmed Cell Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Inclusion Body Assembly Positive Regulation Of Proteasomal Protein Catabolic Process
Pathways		Intraflagellar transport Intra-Golgi traffic Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis ROS sensing by NFE2L2 RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) FEV1 ( 30804560) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Height ( 28552196 20881960 25282103 25429064 31562340 18391950 18391951) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082 30804560) Major depressive disorder ( 34099189) Major depressive disorder x sex interaction ( 34099189) Refractive error ( 32231278) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500)
Interacting Genes		10 interacting genes: ARNT ASB2 ATXN1L EPS8 GPR65 MYBPC2 PSMC5 RB1 SERPINA4 THRA	81 interacting genes: AKT1 AZIN2 BACH2 BFSP2 CAMK2A CCDC136 CDC42 CFAP206 EPHA8 ERCC3 ERCC6 ESR1 ESR2 ESRRA ESRRG FOS FXR1 GTF2B HARS1 HNF4G HOMER3 HSPA1A HTT INSIG2 KRT15 KRT27 KRT31 KRT38 KRT40 LAMB1 LAMC1 MDM2 MYO18B NR1H3 NR1I2 NR1I3 NR3C2 OGT PDC PDCL PLEKHO1 PPARD PRKN PSMC1 PSMC2 PSMC3 PSMC4 PSMC6 PSMD11 PSMD12 RAD23A RARA RARB RARG RORA RORB RORC RXRA SCOC SHOC2 SIRPA SKA1 SP1 SSNA1 SUMO2 TAF10 TFIP11 THAP11 THRB TNNI2 TNNI3 TNNT1 TP53 TPM1 TPM3 TRIP11 UBE3C UBLCP1 USP4 VDR VIM
Entrez ID		9321	5705
HPRD ID		05143	03400
Ensembl ID		ENSG00000100815	ENSG00000087191
Uniprot IDs		Q15643	A0A140VJS3 P62195
PDB IDs			2KRK 3KW6 5GJQ 5GJR 5L4G 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 5VHS 6MSB 6MSD 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN
Enriched GO Terms of Interacting Partners?
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