SOCS6 and EFEMP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		SOCS6	EFEMP1
Description		suppressor of cytokine signaling 6	EGF containing fibulin extracellular matrix protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Phosphatidylinositol 3-kinase Complex	Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Epidermal Growth Factor-activated Receptor Activity Epidermal Growth Factor Receptor Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Growth Factor Activity
	Biological Process	Defense Response Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Regulation Of Growth Regulation Of Phosphatidylinositol 3-kinase Activity Phosphatidylinositol Phosphate Biosynthetic Process Negative Regulation Of T Cell Activation	Regulation Of Transcription, DNA-templated Epidermal Growth Factor Receptor Signaling Pathway Visual Perception Peptidyl-tyrosine Phosphorylation Negative Regulation Of Chondrocyte Differentiation Camera-type Eye Development Embryonic Eye Morphogenesis Post-embryonic Eye Morphogenesis
Pathways		Regulation of KIT signaling Neddylation Negative regulation of FLT3	Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases
GWAS		Diverticular disease ( 30177863) Night sleep phenotypes ( 27126917) Systemic lupus erythematosus ( 18204098) Type 2 diabetes ( 29621232)	Amyotrophic lateral sclerosis ( 19451621) Blood protein levels ( 30072576) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body shape index ( 34021172) Carpal tunnel syndrome ( 30833571) Childhood ear infection ( 27182965 28928442) Chronic venous disease ( 28374850) Deep white matter hyperintensities ( 32517579) Diastolic blood pressure ( 30578418) Diverticular disease ( 30177863) FEV1 ( 30804560) Glaucoma (primary open-angle) ( 33627673) Height ( 28552196 20881960 25282103 25429064 19396169 19893584 23563607 31562340 18391951 18391952 20397748 33713608 20189936) Hip circumference adjusted for BMI ( 34021172 25673412) Inguinal hernia ( 26686553) Intraocular pressure ( 29617998 29785010 30054594 29235454) Joint mobility (Beighton score) ( 27182965) Lung function (FEV1/FVC) ( 30804560) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Lung volume ( 34128465) Metabolite levels ( 23823483) Optic cup area ( 25631615 28073927) Pelvic organ prolapse ( 32184442) Pelvic organ prolapse (moderate/severe) ( 26545240) Periventricular white matter hyperintensities ( 32517579) Pulse pressure ( 27841878 30578418) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 34021172 26785701 25673412 28448500) Waist-hip index ( 34021172) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218) White matter hyperintensity volume ( 29752348 30659137 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		40 interacting genes: ACVR1 AMOT APPL1 AR BMPR1B C1orf109 CLNK CRK DAB1 EFEMP1 EGFR ELOB ELOC ERBB2 ERBB3 ERBB4 FRS3 GAB1 INSR IRS2 IRS4 KDM1A KIT LNX1 MET PIK3R1 PIK3R2 PIK3R3 PITRM1 RBCK1 RELA SMURF2 TGFBR1 TUBA1A TUBB4B TXK UBE2D2 UBE2I WDR89 ZMIZ2	47 interacting genes: ANAPC11 ARAF ATN1 ATXN7 BAG4 BAG5 BAG6 CACNA1A CACNA1C CLPP CRYBA4 CYSRT1 DDIAS ERRFI1 FAM110A GFI1B HOXA1 HSD3B7 IGFBP6 KHDRBS1 KRTAP19-2 KRTAP21-2 KRTAP6-1 LCE1C LCE2C LCE3A LCE3D MEOX2 MKRN3 MSRB3 NLGN3 NOS3 NR4A3 NUFIP2 RAF1 RERE RIC8A SGTA SHANK3 SLPI SOCS6 TIMP3 TNIP1 TRAF2 TXNDC5 UBQLN2 XPO1
Entrez ID		9306	2202
HPRD ID		05491	03331
Ensembl ID		ENSG00000170677	ENSG00000115380
Uniprot IDs		A0A024R379 O14544	A0A0S2Z3V1 A0A0S2Z4F1 B2R6M6 Q12805
PDB IDs		2VIF
Enriched GO Terms of Interacting Partners?
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