SOCS6 and DAB1

Number of citations of the paper that reports this interaction (PubMedID 24210661)
20

Data Source:
BioGRID (pull down)

		SOCS6	DAB1
Description		suppressor of cytokine signaling 6	DAB adaptor protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Phosphatidylinositol 3-kinase Complex	Cytoplasm Cytosol Brush Border Postsynaptic Density Membrane Neuron Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle Apical Part Of Cell Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Protein Binding Phosphatidylinositol 3-kinase Binding
	Biological Process	Defense Response Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Regulation Of Growth Regulation Of Phosphatidylinositol 3-kinase Activity Phosphatidylinositol Phosphate Biosynthetic Process Negative Regulation Of T Cell Activation	Negative Regulation Of Cell Adhesion Small GTPase Mediated Signal Transduction Midgut Development Adult Walking Behavior Response To Xenobiotic Stimulus Dendrite Development Ventral Spinal Cord Development Cerebellum Structural Organization Hippocampus Development Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Radial Glia Guided Migration Of Purkinje Cell Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Axonogenesis Golgi Localization Lateral Motor Column Neuron Migration
Pathways		Regulation of KIT signaling Neddylation Negative regulation of FLT3	Reelin signalling pathway
Drugs
Diseases
GWAS		Diverticular disease ( 30177863) Night sleep phenotypes ( 27126917) Systemic lupus erythematosus ( 18204098) Type 2 diabetes ( 29621232)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Age at first sexual intercourse ( 34211149) Alzheimer's disease progression score ( 29860282) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Bulimia nervosa ( 23568457) Cardiac troponin-I levels ( 31014085) Coronary artery disease ( 29472232) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Household income (MTAG) ( 31844048) Immune reponse to smallpox (secreted IL-10) ( 22610502) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Kawasaki disease ( 21221998) Lateral orbital frontal cortex volume ( 31530798) Logical memory (delayed recall) in normal cognition ( 29274321) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Pubertal anthropometrics ( 23449627) Risk-taking tendency (4-domain principal component model) ( 30643258) Serum linoleic acid concentration in metabolic syndrome ( 31991592) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference ( 28552196) White matter hyperintensities in ischemic stroke ( 26674333)
Interacting Genes		40 interacting genes: ACVR1 AMOT APPL1 AR BMPR1B C1orf109 CLNK CRK DAB1 EFEMP1 EGFR ELOB ELOC ERBB2 ERBB3 ERBB4 FRS3 GAB1 INSR IRS2 IRS4 KDM1A KIT LNX1 MET PIK3R1 PIK3R2 PIK3R3 PITRM1 RBCK1 RELA SMURF2 TGFBR1 TUBA1A TUBB4B TXK UBE2D2 UBE2I WDR89 ZMIZ2	78 interacting genes: APLP1 APLP2 APP ARID5A BHLHE40 C1orf94 CDK5 CIART CLASRP CRK CRKL DAB2IP DAZAP2 ERBB2 ERBB3 FAM168A HMBOX1 HNRNPLL HYAL3 INPP5D ITGB2 ITGB3 ITGB5 ITGB7 ITSN1 JAK1 JUN KRTAP19-5 KRTAP19-7 KRTAP8-1 LDLR LGALS9B LGALS9C LNX1 LRP1 LRP2 LRP8 MAGED1 MAPK14 MBNL1 MBNL3 MYO6 NAF1 NTAQ1 PAFAH1B1 PCDH18 PIN1 PLCG1 POGZ PPIG PRR20A PTPN11 RAMAC RBFOX1 RBFOX2 RELN RHOXF2 ROR2 SERF2 SIAH1 SIRPB1 SMAP2 SNRPB SOCS6 SOCS7 SRC STRBP TCEA2 TCEANC TMTC3 TOLLIP USP53 VENTX VLDLR ZBTB32 ZC3H10 ZCCHC10 ZNF488
Entrez ID		9306	1600
HPRD ID		05491	04582
Ensembl ID		ENSG00000170677	ENSG00000173406
Uniprot IDs		A0A024R379 O14544	O75553
PDB IDs		2VIF
Enriched GO Terms of Interacting Partners?
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