SOCS6 and WDR89

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		SOCS6	WDR89
Description		suppressor of cytokine signaling 6	WD repeat domain 89
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Phosphatidylinositol 3-kinase Complex
	Molecular Function	Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Defense Response Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Regulation Of Growth Regulation Of Phosphatidylinositol 3-kinase Activity Phosphatidylinositol Phosphate Biosynthetic Process Negative Regulation Of T Cell Activation
Pathways		Regulation of KIT signaling Neddylation Negative regulation of FLT3
Drugs
Diseases
GWAS		Diverticular disease ( 30177863) Night sleep phenotypes ( 27126917) Systemic lupus erythematosus ( 18204098) Type 2 diabetes ( 29621232)	Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383)
Interacting Genes		40 interacting genes: ACVR1 AMOT APPL1 AR BMPR1B C1orf109 CLNK CRK DAB1 EFEMP1 EGFR ELOB ELOC ERBB2 ERBB3 ERBB4 FRS3 GAB1 INSR IRS2 IRS4 KDM1A KIT LNX1 MET PIK3R1 PIK3R2 PIK3R3 PITRM1 RBCK1 RELA SMURF2 TGFBR1 TUBA1A TUBB4B TXK UBE2D2 UBE2I WDR89 ZMIZ2	5 interacting genes: APP PHYHIP POLR2M POLR3F SOCS6
Entrez ID		9306	112840
HPRD ID		05491	12635
Ensembl ID		ENSG00000170677	ENSG00000140006
Uniprot IDs		A0A024R379 O14544	A0A024R667 Q96FK6
PDB IDs		2VIF
Enriched GO Terms of Interacting Partners?
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