BUB3 and RBBP7

Number of citations of the paper that reports this interaction (PubMedID 31911655)
3

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		BUB3	RBBP7
Description		BUB3 mitotic checkpoint protein	RB binding protein 7, chromatin remodeling factor
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Nucleoplasm Cytosol Mitotic Checkpoint Complex Bub1-bub3 Complex	Histone Deacetylase Complex Nucleus Nucleoplasm Cytosol NuRD Complex ESC/E(Z) Complex
	Molecular Function	Protein Binding Ubiquitin Binding	RNA Binding Protein Binding Histone Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Spindle Assembly Checkpoint Signaling Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Kinetochore Cell Division Meiotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Chromatin Organization Negative Regulation Of Cell Growth Response To Steroid Hormone Cellular Heat Acclimation
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	PRC2 methylates histones and DNA Oxidative Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines HATs acetylate histones RMTs methylate histone arginines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Activation of anterior HOX genes in hindbrain development during early embryogenesis Deposition of new CENPA-containing nucleosomes at the centromere Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Neddylation Transcriptional Regulation by E2F6 HCMV Early Events Potential therapeutics for SARS Defective pyroptosis
Drugs
Diseases
GWAS		Body mass index ( 28892062) Childhood asthma exacerbations in long-acting beta2-agonist treatment ( 33706416) Left-handedness ( 32989287) Lung volume ( 34128465) Menopause (age at onset) ( 24045676) Right lateral prefrontal cortical growth ( 29682794)	Refractive error ( 32231278)
Interacting Genes		17 interacting genes: BUB1 BUB1B CPNE1 EXOC3 HDAC1 HDAC2 PARP1 PARP2 PSTPIP1 PTEN RBBP7 RPL37A SUGT1 THRA TOP1 UBA1 WBP4	35 interacting genes: APPL1 APPL2 BCL11A BCL11B BRCA1 BRMS1 BRMS1L BUB3 CREBBP CYTOR DHX30 ERCC6 ESR1 FOXK2 H3-4 H3C1 HDAC1 HDAC2 HUWE1 ING1 MBD3 MBD3L2 MTA2 NR2E3 OGT PRKAA2 RB1 RBBP4 RBP1 SALL2 SAP30 SIN3A SUMO2 SUV39H1 TWIST1
Entrez ID		9184	5931
HPRD ID		04761	04231
Ensembl ID		ENSG00000154473	ENSG00000102054
Uniprot IDs		A0A140VJF3 O43684	Q16576 Q6FHQ0
PDB IDs			3CFS 3CFV
Enriched GO Terms of Interacting Partners?
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