BUB3 and CPNE1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		BUB3	CPNE1
Description		BUB3 mitotic checkpoint protein	copine 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Kinetochore Nucleoplasm Cytosol Mitotic Checkpoint Complex Bub1-bub3 Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Membrane Azurophil Granule Membrane Extracellular Exosome
	Molecular Function	Protein Binding Ubiquitin Binding	Phosphatidylserine Binding Endopeptidase Activity Transporter Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Identical Protein Binding NF-kappaB Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Spindle Assembly Checkpoint Signaling Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Kinetochore Cell Division Meiotic Cell Cycle	Proteolysis Lipid Metabolic Process Negative Regulation Of Gene Expression Vesicle-mediated Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of DNA Binding Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Calcium Ion Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Neuron Projection Extension
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Glycerophospholipid biosynthesis Neutrophil degranulation
Drugs			Theophylline
Diseases
GWAS		Body mass index ( 28892062) Childhood asthma exacerbations in long-acting beta2-agonist treatment ( 33706416) Left-handedness ( 32989287) Lung volume ( 34128465) Menopause (age at onset) ( 24045676) Right lateral prefrontal cortical growth ( 29682794)	Blood protein levels ( 30072576 29875488 28240269) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		17 interacting genes: BUB1 BUB1B CPNE1 EXOC3 HDAC1 HDAC2 PARP1 PARP2 PSTPIP1 PTEN RBBP7 RPL37A SUGT1 THRA TOP1 UBA1 WBP4	21 interacting genes: ACTB BCOR BUB3 CCDC22 CPNE4 LHX6 LIG4 MAP2K1 MYCBP PDCD6 PITPNM2 PPP5C RDX SKIL SORBS3 SPTBN1 STK3 TRPC4AP UBE2M UBE2O WTAP
Entrez ID		9184	8904
HPRD ID		04761	05014
Ensembl ID		ENSG00000154473	ENSG00000214078
Uniprot IDs		A0A140VJF3 O43684	B0QZ18 Q99829
PDB IDs
Enriched GO Terms of Interacting Partners?
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