CD3E and ZAP70

Number of citations of the paper that reports this interaction (PubMedID 8366117)
64

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)
HPRD (in vivo, in vitro)

		CD3E	ZAP70
Description		CD3e molecule	zeta chain of T cell receptor associated protein kinase 70
Image
GO Annotations	Cellular Component	Immunological Synapse Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex Dendritic Spine Cell Body	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane T Cell Receptor Complex Membrane Raft
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity T Cell Receptor Binding Identical Protein Binding Protein Heterodimerization Activity	Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Adaptive Immune Response Positive Regulation Of T Cell Anergy Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Complex Assembly G Protein-coupled Receptor Signaling Pathway Response To Nutrient Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Dendrite Development Cerebellum Development T Cell Costimulation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of Apoptotic Process Positive Thymic T Cell Selection Negative Thymic T Cell Selection Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Protein-containing Complex Assembly Apoptotic Signaling Pathway	Adaptive Immune Response Protein Phosphorylation Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Differentiation T Cell Differentiation Intracellular Signal Transduction T Cell Activation B Cell Activation Beta Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Innate Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Protein Autophosphorylation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway T Cell Aggregation T Cell Migration
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PD-1 signaling	Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules RHOH GTPase cycle
Drugs		Muromonab Catumaxomab	Staurosporine Fostamatinib
Diseases
GWAS		Lung cancer in ever smokers ( 28604730) Pulse pressure ( 27841878)	Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cardiac Troponin-T levels ( 31014085) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		28 interacting genes: ADAM33 BNIP3 CD3D CD3G CD79B CSK DRD2 EPS8L1 LCK MUC15 NAT8 NCK1 NCK2 NCL PIK3R1 PKMYT1 POLR1G PTPN22 SHC1 SNTA1 SYK TOP2B TRAT1 TRB UBASH3A UNC119 ZAP70 ZFPL1	67 interacting genes: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK CUL3 DAPK1 DBNL DEF6 DUSP3 EGFR ERBB2 ERBB3 ERBB4 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 KIT LAT LAX1 LCK LCP2 LRRK2 MET MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 RNF41 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP USP2 VAV1 WIPF1
Entrez ID		916	7535
HPRD ID		08923	01495
Ensembl ID		ENSG00000198851	ENSG00000115085
Uniprot IDs		P07766	P43403
PDB IDs		1A81 1SY6 1XIW 2ROL 5QU2 6JXR	1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R 4XZ0 4XZ1 5O76
Enriched GO Terms of Interacting Partners?
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