CD3E and POLR1G

Number of citations of the paper that reports this interaction (PubMedID 10373416)
17

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro, in vivo)

		CD3E	POLR1G
Description		CD3e molecule	RNA polymerase I subunit G
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex Dendritic Spine Cell Body	RNA Polymerase I Transcription Regulator Complex Fibrillar Center Nucleoplasm Chromosome Nucleolus RNA Polymerase I Complex Mitochondrion Cytosol
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity T Cell Receptor Binding Identical Protein Binding Protein Heterodimerization Activity	RNA Binding DNA-directed 5'-3' RNA Polymerase Activity
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Adaptive Immune Response Positive Regulation Of T Cell Anergy Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Complex Assembly G Protein-coupled Receptor Signaling Pathway Response To Nutrient Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Dendrite Development Cerebellum Development T Cell Costimulation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of Apoptotic Process Positive Thymic T Cell Selection Negative Thymic T Cell Selection Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Protein-containing Complex Assembly Apoptotic Signaling Pathway	Transcription By RNA Polymerase I Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway RRNA Transcription
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PD-1 signaling	NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs		Muromonab Catumaxomab
Diseases
GWAS		Lung cancer in ever smokers ( 28604730) Pulse pressure ( 27841878)
Interacting Genes		28 interacting genes: ADAM33 BNIP3 CD3D CD3G CD79B CSK DRD2 EPS8L1 LCK MUC15 NAT8 NCK1 NCK2 NCL PIK3R1 PKMYT1 POLR1G PTPN22 SHC1 SNTA1 SYK TOP2B TRAT1 TRB UBASH3A UNC119 ZAP70 ZFPL1	7 interacting genes: ANK3 CD3E NFKBIB POLR1C POLR1E TAF1A UBTF
Entrez ID		916	10849
HPRD ID		08923	00125
Ensembl ID		ENSG00000198851	ENSG00000117877
Uniprot IDs		P07766	O15446
PDB IDs		1A81 1SY6 1XIW 2ROL 5QU2 6JXR
Enriched GO Terms of Interacting Partners?
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