USP10 and SCNN1A

Number of citations of the paper that reports this interaction (PubMedID 18632802)
26

Data Source:
HPRD (in vivo)

		USP10	SCNN1A
Description		ubiquitin specific peptidase 10	sodium channel epithelial 1 subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Early Endosome Cytosol Protein-containing Complex Intermediate Filament Cytoskeleton	Acrosomal Vesicle Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Motile Cilium Sodium Channel Complex Ciliary Membrane Extracellular Exosome Sperm Principal Piece
	Molecular Function	P53 Binding RNA Binding Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Transmembrane Transporter Binding	Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Autophagy Cellular Response To DNA Damage Stimulus Regulation Of Autophagy Protein Deubiquitination Translesion Synthesis DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Interleukin-1	Sodium Ion Transmembrane Transport Multicellular Organismal Water Homeostasis Response To Stimulus Sensory Perception Of Taste Sodium Ion Homeostasis
Pathways		Termination of translesion DNA synthesis Ub-specific processing proteases	Stimuli-sensing channels
Drugs			Triamterene Amiloride
Diseases
GWAS		Copper levels ( 26025379) Height ( 18391951) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Plasma factor VII activating protease levels ( 30070759) Response to mTOR inhibitor (everolimus) ( 24009623) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)	Adverse response to drug ( 30420678) Alopecia areata ( 25608926) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity (early onset extreme) ( 23563609) Primary biliary cirrhosis ( 22961000) Spleen volume ( 34128465)
Interacting Genes		20 interacting genes: AR G3BP1 H2AC20 HDAC6 IKBKG KLF4 MAP1LC3B MSH2 NOTCH1 PRKAA2 RACK1 RAD51 SCNN1A SCNN1G SIRT6 SMAD4 SNX3 UBC WWTR1 YAP1	18 interacting genes: COMMD10 CSNK2A1 EPN1 HECW1 ITCH NEDD4 NEDD4L NPC2 SCNN1B SCNN1G SERP1 SNX3 STX1A TSG101 UBE2I USP10 WWP1 WWP2
Entrez ID		9100	6337
HPRD ID		07029	02575
Ensembl ID		ENSG00000103194	ENSG00000111319
Uniprot IDs		A0A7G6J4N4 Q14694	P37088
PDB IDs			2M3O 6BQN 6WTH
Enriched GO Terms of Interacting Partners?
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