USP10 and YAP1

Number of citations of the paper that reports this interaction (PubMedID 32217697)
12

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology)

		USP10	YAP1
Description		ubiquitin specific peptidase 10	Yes1 associated transcriptional regulator
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Early Endosome Cytosol Protein-containing Complex Intermediate Filament Cytoskeleton	Female Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm Cytosol Membrane TEAD-YAP Complex
	Molecular Function	P53 Binding RNA Binding Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Transmembrane Transporter Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Proline-rich Region Binding DNA-binding Transcription Factor Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Autophagy Cellular Response To DNA Damage Stimulus Regulation Of Autophagy Protein Deubiquitination Translesion Synthesis DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Interleukin-1	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Vasculogenesis Trophectodermal Cell Differentiation Tissue Homeostasis Heart Process Embryonic Heart Tube Morphogenesis Cellular Response To DNA Damage Stimulus Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Negative Regulation Of Epithelial Cell Differentiation Notochord Development Response To Progesterone Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Hippo Signaling Wound Healing Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Development Lateral Mesoderm Development Positive Regulation Of Epithelial Cell Proliferation Regulation Of Neurogenesis Progesterone Receptor Signaling Pathway Positive Regulation Of Cardiac Muscle Cell Proliferation Contact Inhibition Bud Elongation Involved In Lung Branching Lung Epithelial Cell Differentiation Intestinal Epithelial Cell Development Cardiac Muscle Tissue Regeneration Protein-containing Complex Assembly Interleukin-6-mediated Signaling Pathway Cellular Response To Retinoic Acid Cellular Response To Gamma Radiation Regulation Of Stem Cell Proliferation Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Termination of translesion DNA synthesis Ub-specific processing proteases	Nuclear signaling by ERBB4 Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS		Copper levels ( 26025379) Height ( 18391951) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Plasma factor VII activating protease levels ( 30070759) Response to mTOR inhibitor (everolimus) ( 24009623) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)	Cleft palate ( 27018472) Colorectal cancer or advanced adenoma ( 30510241) Heel bone mineral density ( 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Migraine ( 27322543) Offspring birth weight ( 31043758) Polycystic ovary syndrome ( 22885925 30566500 26416764) Prostate cancer ( 23535732) Pubertal anthropometrics ( 23449627) Pulse pressure ( 30224653 30578418) Reticulocyte count ( 32888494) Whole-brain volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		20 interacting genes: AR G3BP1 H2AC20 HDAC6 IKBKG KLF4 MAP1LC3B MSH2 NOTCH1 PRKAA2 RACK1 RAD51 SCNN1A SCNN1G SIRT6 SMAD4 SNX3 UBC WWTR1 YAP1	37 interacting genes: ABL1 AKT1 CD28 EIF3H ENAH ERBB4 GAS5 HNRNPU KIF5A LINC00839 NFE2 OTUD1 PRRG2 PRRG4 PTCH1 PTEN PTPN21 RUNX1 RUNX2 RUNX3 SCAMP3 SLC9A3R1 SMAD1 SMAD7 SUMO3 TEAD1 TEAD2 TEAD3 TEAD4 TP53BP2 TP73 USP10 WBP1 WBP2 YWHAG YWHAQ YWHAZ
Entrez ID		9100	10413
HPRD ID		07029	09424
Ensembl ID		ENSG00000103194	ENSG00000137693
Uniprot IDs		A0A7G6J4N4 Q14694	A0A024R3E4 K0KVU2 P46937 Q86T74
PDB IDs			1JMQ 1K5R 1K9Q 1K9R 2LAW 2LAX 2LAY 2LTV 2LTW 3KYS 3MHR 4RE1 4REX 5OAQ 5YDX 5YDY 6G6X 6G8I 6G8J 6G8K 6G8L 6G8P 6G8Q 6GE3 6GE4 6GE5 6GE6 6GEC 6GEE 6GEG 6GEI 6GEK 6HIK 6HIL 6Q2X
Enriched GO Terms of Interacting Partners?
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