PAPSS2 and TLL2

		PAPSS2	TLL2
Description		3'-phosphoadenosine 5'-phosphosulfate synthase 2	tolloid like 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Extracellular Region
	Molecular Function	Adenylylsulfate Kinase Activity Sulfate Adenylyltransferase (ATP) Activity Protein Binding ATP Binding Nucleotidyltransferase Activity	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Zinc Ion Binding
	Biological Process	Sulfate Assimilation Skeletal System Development Phosphorylation 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process	Proteolysis Cell Differentiation Collagen Fibril Organization Negative Regulation Of Skeletal Muscle Tissue Growth
Pathways		Transport and synthesis of PAPS Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Defective PAPSS2 causes SEMD-PA	Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils
Drugs			Methyl N-{[(1R)-1-({1-[(benzyloxy)carbonyl]-L-prolyl-6-ammonio-L-norleucyl}amino)-2-phenylethyl](hydroxy)phosphoryl}-L-alanyl-L-prolinate
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) Leisure-time exercise behaviour ( 19727025) Magnesium levels ( 26685716) Serum metabolite levels ( 33031748)	Attention deficit hyperactivity disorder ( 18839057) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Platelet reactivity in response to clopidogrel treatment ( 32472697) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770)
Interacting Genes		6 interacting genes: APP CD83 CEP19 DAPK1 HSF2BP TLL2	5 interacting genes: DNTT HPSE2 PAPSS2 PPP1R3C RBP4
Entrez ID		9060	7093
HPRD ID		04303	05993
Ensembl ID		ENSG00000198682	ENSG00000095587
Uniprot IDs		O95340 Q5TB52	Q9Y6L7
PDB IDs		2AX4
Enriched GO Terms of Interacting Partners?
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