TLL2 and PAPSS2

		TLL2	PAPSS2
Description		tolloid like 2	3'-phosphoadenosine 5'-phosphosulfate synthase 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Cytosol
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Zinc Ion Binding	Adenylylsulfate Kinase Activity Sulfate Adenylyltransferase (ATP) Activity Protein Binding ATP Binding Nucleotidyltransferase Activity
	Biological Process	Proteolysis Cell Differentiation Collagen Fibril Organization Negative Regulation Of Skeletal Muscle Tissue Growth	Sulfate Assimilation Skeletal System Development Phosphorylation 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process
Pathways		Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils	Transport and synthesis of PAPS Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Defective PAPSS2 causes SEMD-PA
Drugs		Methyl N-{[(1R)-1-({1-[(benzyloxy)carbonyl]-L-prolyl-6-ammonio-L-norleucyl}amino)-2-phenylethyl](hydroxy)phosphoryl}-L-alanyl-L-prolinate
Diseases
GWAS		Attention deficit hyperactivity disorder ( 18839057) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Platelet reactivity in response to clopidogrel treatment ( 32472697) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) Leisure-time exercise behaviour ( 19727025) Magnesium levels ( 26685716) Serum metabolite levels ( 33031748)
Interacting Genes		5 interacting genes: DNTT HPSE2 PAPSS2 PPP1R3C RBP4	6 interacting genes: APP CD83 CEP19 DAPK1 HSF2BP TLL2
Entrez ID		7093	9060
HPRD ID		05993	04303
Ensembl ID		ENSG00000095587	ENSG00000198682
Uniprot IDs		Q9Y6L7	O95340 Q5TB52
PDB IDs			2AX4
Enriched GO Terms of Interacting Partners?
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