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USP13 and DVL1
Number of citations of the paper that reports this interaction (PubMedID
16169070
)
888
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
USP13
DVL1
Description
ubiquitin specific peptidase 13
dishevelled segment polarity protein 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Cytosol
Microtubule
Postsynaptic Density
Lateral Plasma Membrane
Clathrin-coated Vesicle
Growth Cone
Cytoplasmic Vesicle
Neuron Projection
Neuronal Cell Body
Dendritic Spine
Synapse
Schaffer Collateral - CA1 Synapse
Presynapse
Glutamatergic Synapse
Wnt Signalosome
Molecular Function
Cysteine-type Endopeptidase Activity
Thiol-dependent Deubiquitinase
Protein Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
Ubiquitin Binding
Ubiquitin-like Protein Ligase Binding
Chaperone Binding
Proteasome Binding
BAT3 Complex Binding
Lys48-specific Deubiquitinase Activity
Molecular_function
Frizzled Binding
Protein Binding
Beta-catenin Binding
Enzyme Binding
Protein Kinase Binding
Small GTPase Binding
Identical Protein Binding
Biological Process
Regulation Of Transcription, DNA-templated
Ubiquitin-dependent Protein Catabolic Process
Autophagy
Cell Population Proliferation
Regulation Of Autophagy
Protein Deubiquitination
Melanocyte Differentiation
Protein K29-linked Deubiquitination
Protein K6-linked Deubiquitination
Protein Stabilization
Protein K63-linked Deubiquitination
Protein K48-linked Deubiquitination
Positive Regulation Of ERAD Pathway
Maintenance Of Unfolded Protein Involved In ERAD Pathway
Regulation Of Neurotransmitter Levels
Positive Regulation Of Protein Phosphorylation
Regulation Of Transcription, DNA-templated
Negative Regulation Of Protein Kinase Activity
Neurotransmitter Secretion
Axon Guidance
Heart Development
Neuromuscular Junction Development
Positive Regulation Of Neuron Projection Development
Neural Tube Development
Convergent Extension Involved In Neural Plate Elongation
Cytoplasmic Microtubule Organization
Negative Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Localization To Nucleus
Social Behavior
Protein Localization To Microtubule
Intracellular Signal Transduction
Non-canonical Wnt Signaling Pathway
Receptor Clustering
Positive Regulation Of Transcription By RNA Polymerase II
Collateral Sprouting
Axon Extension
Dendrite Morphogenesis
Synapse Organization
Protein Stabilization
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Prepulse Inhibition
Dendritic Spine Morphogenesis
Skeletal Muscle Acetylcholine-gated Channel Clustering
Cochlea Morphogenesis
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Presynapse Assembly
Positive Regulation Of Neuron Projection Arborization
Regulation Of Cellular Protein Localization
Positive Regulation Of Protein Localization To Presynapse
Regulation Of Synaptic Vesicle Exocytosis
Positive Regulation Of Excitatory Postsynaptic Potential
Pathways
Ub-specific processing proteases
Regulation of PTEN stability and activity
TCF dependent signaling in response to WNT
WNT mediated activation of DVL
PCP/CE pathway
PCP/CE pathway
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
RHO GTPases Activate Formins
WNT5:FZD7-mediated leishmania damping
WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS
Inflammatory bowel disease (
28067908
)
Nicotine dependence (
32281736
)
Ulcerative colitis (
28067908
)
Interacting Genes
24 interacting genes:
AMFR
BAG6
CLK3
DAZAP2
DVL1
FNBP1L
FUNDC2
GPR160
HSP90AA1
LAPTM5
MCL1
MDC1
MRPL20
MYO15A
S100A9
SIAH2
SPRR2C
SYCP2
TRA2B
TRIM55
TRIM63
UBC
UBL4A
UIMC1
42 interacting genes:
ANXA7
ARRB1
ATN1
AXIN1
BAG3
BRD7
BUB1
CCDC88C
CSNK1D
CSNK1E
CSNK2A1
CTNNB1
CXXC4
DAAM1
DAB2
DVL3
DYNLT1
EPS8
FBXW7
FRAT1
HDHD2
HECW1
LRRK2
MLH3
MSH2
NCK2
NEDD4
PPM1A
PSMA3
RAC1
RB1
SIPA1
SMAD1
SMAD2
SMAD3
SMAD4
SMAD7
SMYD1
TRIM69
USP13
VANGL1
VANGL2
Entrez ID
8975
1855
HPRD ID
04666
03220
Ensembl ID
ENSG00000058056
ENSG00000107404
Uniprot IDs
A0A0A6YZ17
Q92995
O14640
PDB IDs
2L80
2LBC
6LCA
6LCB
6TTK
Enriched GO Terms of Interacting Partners
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