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SQSTM1 and TBK1
Number of citations of the paper that reports this interaction (PubMedID
27035970
)
209
Data Source:
BioGRID
(enzymatic study, affinity chromatography technology)
SQSTM1
TBK1
Description
sequestosome 1
TANK binding kinase 1
Image
GO Annotations
Cellular Component
Phagophore Assembly Site
P-body
Nucleoplasm
Cytoplasm
Mitochondrion
Late Endosome
Autophagosome
Endoplasmic Reticulum
Cytosol
Inclusion Body
Aggresome
PML Body
Sarcomere
Intracellular Membrane-bounded Organelle
Amphisome
Autolysosome
Extracellular Exosome
Sperm Midpiece
Lewy Body
Nucleoplasm
Cytoplasm
Cytosol
Intracellular Membrane-bounded Organelle
Molecular Function
Protein Serine/threonine Kinase Activity
Protein Kinase C Binding
Protein Binding
Zinc Ion Binding
Enzyme Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Ubiquitin Protein Ligase Binding
Ionotropic Glutamate Receptor Binding
SH2 Domain Binding
Identical Protein Binding
Ubiquitin Binding
Protein-containing Complex Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Nucleic Acid Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Phosphatase Binding
Identical Protein Binding
Phosphoprotein Binding
Protein Serine Kinase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Autophagy Of Mitochondrion
Mitophagy
Positive Regulation Of Protein Phosphorylation
Immune System Process
Response To Ischemia
Protein Phosphorylation
Ubiquitin-dependent Protein Catabolic Process
Autophagy
Apoptotic Process
Endosome Organization
Protein Localization
Regulation Of Mitochondrion Organization
Endosomal Transport
Macroautophagy
Cell Differentiation
Negative Regulation Of Protein Ubiquitination
Intracellular Signal Transduction
Aggrephagy
Positive Regulation Of Apoptotic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Ras Protein Signal Transduction
Regulation Of Protein Complex Stability
Selective Autophagy
Response To Mitochondrial Depolarisation
Positive Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Protein Localization To Plasma Membrane
Protein Localization To Perinuclear Region Of Cytoplasm
Activation Of Innate Immune Response
Protein Phosphorylation
Inflammatory Response
I-kappaB Kinase/NF-kappaB Signaling
Response To Virus
Negative Regulation Of Gene Expression
Positive Regulation Of Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Dendritic Cell Proliferation
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Defense Response To Gram-positive Bacterium
Defense Response To Virus
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Regulation Of Neuron Death
Positive Regulation Of Xenophagy
Pathways
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
PINK1-PRKN Mediated Mitophagy
Interleukin-1 signaling
Pexophagy
Signaling by ALK fusions and activated point mutants
IRF3 mediated activation of type 1 IFN
IRF3 mediated activation of type 1 IFN
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Regulation of innate immune responses to cytosolic DNA
STAT6-mediated induction of chemokines
IRF3-mediated induction of type I IFN
Interleukin-37 signaling
TICAM1-dependent activation of IRF3/IRF7
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Potential therapeutics for SARS
Drugs
Fostamatinib
Diseases
GWAS
Alzheimer's disease (late onset) (
24162737
)
Monocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Amyotrophic lateral sclerosis (
29566793
27455348
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Lung adenocarcinoma (
28604730
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Interacting Genes
108 interacting genes:
ATXN3
BCL2
BMPR1B
BPTF
BRCA1
CALCR
CALM1
CALR
CAMK2A
CCNB1
CDC37
CDC6
CDK1
CRBN
CRYAB
CSNK1A1
CSNK2A1
DAXX
DAZAP2
DNAI1
DNAI2
DNAJC10
EEF1D
FKBP4
GABARAP
GABARAPL1
GABARAPL2
GABRR1
GABRR2
GEMIN4
GRB14
GRIA1
GRIA2
GRIA3
HSPA5
HSPB1
IKBKB
IRAK1
KAT5
KCNAB2
KEAP1
LCK
LINC01554
LRRK2
MALT1
MAP1LC3B
MAP2K5
MAPK13
MAPK14
MAPT
MBP
MEIS2
MLH1
MTDH
NBR1
NCOR1
NEDD4
NR2F2
NSD3
NTRK1
NTRK2
NTRK3
OGT
PADI1
PAWR
PIK3CA
PIK3R1
PPHLN1
PRKCD
PRKCI
PRKCZ
RAD23A
RAD54L2
RELN
RIPK1
RNF166
RNF168
RPL37
SKP2
SLIT3
SMAD1
SMAD2
SMAD3
SMAD4
SMURF1
SNCA
STXBP1
TBK1
TGFBR1
TKT
TOE1
TP53INP1
TRAF6
TRIB3
TRIM21
TRIM55
TRIM63
TTN
UBA52
UBB
UBE2D2
UBE2D3
ULK2
USP8
VANGL2
WDR81
XIAP
YWHAZ
53 interacting genes:
AGAP2
AGO2
APP
ATG9A
AVIL
AZI2
CALCOCO2
CDC37
CDC42BPG
CRTC1
CYLD
HSP90AA1
HSP90AB1
IKBKB
IKBKG
IRF3
IRF5
IRF7
MAP1LC3B
MARCHF9
MAVS
MBP
MIB2
MPP3
MTPAP
NCK1
NEDD4
NFKBIA
PROS1
PTPRD
RELA
RIPK1
RNF128
RPS6KB1
SCN7A
SIKE1
SMCR8
SMURF1
SOCS2
SQSTM1
STX11
TANK
TICAM1
TRAF2
TRAF3
TRAF3IP2
TRAF5
TRIM21
TRIM27
TXLNG
UBQLN2
XIAP
YAF2
Entrez ID
8878
29110
HPRD ID
03319
05322
Ensembl ID
ENSG00000161011
ENSG00000183735
Uniprot IDs
Q13501
Q9UHD2
PDB IDs
1Q02
2JY7
2JY8
2K0B
2KNV
4MJS
4UF8
4UF9
5YP7
5YP8
5YPA
5YPB
5YPC
5YPE
5YPF
5YPG
5YPH
6JM4
6KHZ
6MJ7
6TGY
6TH3
4EFO
4EUT
4EUU
4IM0
4IM2
4IM3
4IW0
4IWO
4IWP
4IWQ
5EOA
5EOF
5EP6
5W5V
6BNY
6BOD
6BOE
6CQ0
6CQ4
6CQ5
6NT9
6O8B
6RSR
6RST
6RSU
Enriched GO Terms of Interacting Partners
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