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TBK1 and CYLD
Number of citations of the paper that reports this interaction (PubMedID
29755980
)
8
Data Source:
BioGRID
(enzymatic study)
TBK1
CYLD
Description
TANK binding kinase 1
CYLD lysine 63 deubiquitinase
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Intracellular Membrane-bounded Organelle
Centrosome
Spindle
Cytosol
Cytoplasmic Microtubule
Midbody
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Ciliary Basal Body
Perinuclear Region Of Cytoplasm
Ciliary Tip
Molecular Function
Nucleic Acid Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Phosphatase Binding
Identical Protein Binding
Phosphoprotein Binding
Protein Serine Kinase Activity
Thiol-dependent Deubiquitinase
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Lys63-specific Deubiquitinase Activity
Proline-rich Region Binding
Biological Process
Activation Of Innate Immune Response
Protein Phosphorylation
Inflammatory Response
I-kappaB Kinase/NF-kappaB Signaling
Response To Virus
Negative Regulation Of Gene Expression
Positive Regulation Of Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Dendritic Cell Proliferation
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Defense Response To Gram-positive Bacterium
Defense Response To Virus
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Regulation Of Neuron Death
Positive Regulation Of Xenophagy
Ubiquitin-dependent Protein Catabolic Process
Cell Cycle
Regulation Of Mitotic Cell Cycle
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Wnt Signaling Pathway
Protein Deubiquitination
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Type I Interferon Production
Innate Immune Response
Negative Regulation Of JNK Cascade
Regulation Of Inflammatory Response
Regulation Of Necroptotic Process
Necroptotic Process
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Regulation Of Microtubule Cytoskeleton Organization
Protein K63-linked Deubiquitination
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of NIK/NF-kappaB Signaling
Regulation Of Cilium Assembly
Negative Regulation Of P38MAPK Cascade
Protein Linear Deubiquitination
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
IRF3 mediated activation of type 1 IFN
IRF3 mediated activation of type 1 IFN
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Regulation of innate immune responses to cytosolic DNA
STAT6-mediated induction of chemokines
IRF3-mediated induction of type I IFN
Interleukin-37 signaling
TICAM1-dependent activation of IRF3/IRF7
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Potential therapeutics for SARS
NOD1/2 Signaling Pathway
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases
Negative regulators of DDX58/IFIH1 signaling
Drugs
Fostamatinib
Diseases
GWAS
Amyotrophic lateral sclerosis (
29566793
27455348
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Lung adenocarcinoma (
28604730
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Adventurousness (
30643258
)
Asthma (childhood onset) (
31036433
)
Asthma (time to onset) (
27130862
)
Body mass index (
28892062
)
Crohn's disease (
28067908
22412388
)
Femoral neck bone mineral density (
29499414
)
General risk tolerance (MTAG) (
30643258
)
Heel bone mineral density (
30598549
)
Inflammatory bowel disease (
28067908
)
Leprosy (
25642632
22019778
)
Lumbar spine bone mineral density (
29499414
22504420
)
Serum metabolite levels (
33031748
)
Interacting Genes
53 interacting genes:
AGAP2
AGO2
APP
ATG9A
AVIL
AZI2
CALCOCO2
CDC37
CDC42BPG
CRTC1
CYLD
HSP90AA1
HSP90AB1
IKBKB
IKBKG
IRF3
IRF5
IRF7
MAP1LC3B
MARCHF9
MAVS
MBP
MIB2
MPP3
MTPAP
NCK1
NEDD4
NFKBIA
PROS1
PTPRD
RELA
RIPK1
RNF128
RPS6KB1
SCN7A
SIKE1
SMCR8
SMURF1
SOCS2
SQSTM1
STX11
TANK
TICAM1
TRAF2
TRAF3
TRAF3IP2
TRAF5
TRIM21
TRIM27
TXLNG
UBQLN2
XIAP
YAF2
24 interacting genes:
AKT1
AURKB
CENPV
DDX58
DLG4
HDAC6
IKBKE
IKBKG
ITCH
MAP3K7
MAPRE1
MIB2
PLK4
PTPA
TBK1
TP53
TRAF2
TRAF6
TRAF7
TRAIP
TRIM47
TUBA1A
UBC
UBE2S
Entrez ID
29110
1540
HPRD ID
05322
05427
Ensembl ID
ENSG00000183735
ENSG00000083799
Uniprot IDs
Q9UHD2
A0A024R6T1
Q9NQC7
PDB IDs
4EFO
4EUT
4EUU
4IM0
4IM2
4IM3
4IW0
4IWO
4IWP
4IWQ
5EOA
5EOF
5EP6
5W5V
6BNY
6BOD
6BOE
6CQ0
6CQ4
6CQ5
6NT9
6O8B
6RSR
6RST
6RSU
1IXD
1WHL
1WHM
2VHF
Enriched GO Terms of Interacting Partners
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