SOCS2 and RYBP

Number of citations of the paper that reports this interaction (PubMedID 20543098)
20

Data Source:
BioGRID (two hybrid)

		SOCS2	RYBP
Description		suppressor of cytokine signaling 2	RING1 and YY1 binding protein
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GO Annotations	Cellular Component	Cytoplasm Cytosol Phosphatidylinositol 3-kinase Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Growth Hormone Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding JAK Pathway Signal Transduction Adaptor Activity 1-phosphatidylinositol-3-kinase Regulator Activity	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Receptor Signaling Pathway Via JAK-STAT Lactation Regulation Of Signal Transduction Protein Ubiquitination Response To Estradiol Cellular Response To Hormone Stimulus Intracellular Signal Transduction Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Neuron Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Phosphatidylinositol Phosphate Biosynthetic Process Growth Hormone Receptor Signaling Pathway Mammary Gland Alveolus Development	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Apoptotic Process Multicellular Organism Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Histone H2A Monoubiquitination Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated
Pathways		Interleukin-7 signaling Neddylation Negative regulation of FLT3 Growth hormone receptor signaling	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Height ( 28552196 20881960 25282103 25429064 23563607 31562340 18391951 18391952) Hepatic lipid content in extreme obesity ( 25246029) Hip circumference adjusted for BMI ( 34021172) Joint damage in rheumatoid arthritis ( 31596875) Pubertal anthropometrics ( 23449627) Type 2 diabetes ( 30054458)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Body size at age 10 ( 32376654) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 28552196 20881960 25282103 25429064 23563607 31562340) Hip circumference adjusted for BMI ( 34021172) Medication use (beta blocking agents) ( 31015401) Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Resting-state electroencephalogram vigilance ( 29703947) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500)
Interacting Genes		20 interacting genes: ARFIP2 BMI1 EGFR EPOR ERBB3 ERBB4 GHR IGF1R INSR KIT MET PLA2G1B PRLR PTK2 RYBP SOCS3 STK16 TBK1 TPD52 YES1	34 interacting genes: ABL1 BANP CASP10 CASP8 CBX2 CRK E2F2 E2F3 E2F4 E2F6 EAF1 FADD FANK1 FHL3 GABPB1 GABPB2 HSPB1 MAPK8IP2 MDM2 NMI NOS1AP PSMB1 PTEN RBBP4 RING1 RNF2 RNF8 SOCS2 UBC UBE3A XAGE1A XAGE1B YY1 ZFP42
Entrez ID		8835	23429
HPRD ID		05490	09607
Ensembl ID		ENSG00000120833	ENSG00000163602
Uniprot IDs		A0A024RBD2 O14508	Q8N488
PDB IDs		2C9W 4JGH 5BO4 6I4X 6I5J 6I5N	3IXS
Enriched GO Terms of Interacting Partners?
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