SOCS2 and SOCS3

Number of citations of the paper that reports this interaction (PubMedID 16199887)
48

Data Source:
HPRD (in vitro)

		SOCS2	SOCS3
Description		suppressor of cytokine signaling 2	suppressor of cytokine signaling 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Phosphatidylinositol 3-kinase Complex	Cytosol Phosphatidylinositol 3-kinase Complex
	Molecular Function	Growth Hormone Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding JAK Pathway Signal Transduction Adaptor Activity 1-phosphatidylinositol-3-kinase Regulator Activity	Phosphotyrosine Residue Binding Protein Kinase Inhibitor Activity Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Regulation Of Cell Growth Receptor Signaling Pathway Via JAK-STAT Lactation Regulation Of Signal Transduction Protein Ubiquitination Response To Estradiol Cellular Response To Hormone Stimulus Intracellular Signal Transduction Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Neuron Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Phosphatidylinositol Phosphate Biosynthetic Process Growth Hormone Receptor Signaling Pathway Mammary Gland Alveolus Development	Receptor Signaling Pathway Via JAK-STAT Protein Ubiquitination Intracellular Signal Transduction Regulation Of Growth Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphate Biosynthetic Process Negative Regulation Of Inflammatory Response Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Cellular Response To Leukemia Inhibitory Factor
Pathways		Interleukin-7 signaling Neddylation Negative regulation of FLT3 Growth hormone receptor signaling	Interleukin-6 signaling Signaling by Leptin Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling PTK6 Activates STAT3 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Neddylation Interferon alpha/beta signaling Regulation of IFNA signaling Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Height ( 28552196 20881960 25282103 25429064 23563607 31562340 18391951 18391952) Hepatic lipid content in extreme obesity ( 25246029) Hip circumference adjusted for BMI ( 34021172) Joint damage in rheumatoid arthritis ( 31596875) Pubertal anthropometrics ( 23449627) Type 2 diabetes ( 30054458)	Asthma ( 32296059) Blood trace element (Se levels) ( 23720494) Creatine kinase levels ( 29403010)
Interacting Genes		20 interacting genes: ARFIP2 BMI1 EGFR EPOR ERBB3 ERBB4 GHR IGF1R INSR KIT MET PLA2G1B PRLR PTK2 RYBP SOCS3 STK16 TBK1 TPD52 YES1	64 interacting genes: ABL1 ACADVL APP AR BCL10 BIK BLK CAVIN1 CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR ELOB ELOC EPOR ERBB2 ERBB3 ERBB4 GAB1 GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRF7 IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 KIT LEPR MAP1S MAPK11 MAPK6 MET NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RNF7 RPL7A SH2D2A SOCS2 TES TFDP1 TFR2 TRDN TXK TXNDC11 YES1 YWHAQ
Entrez ID		8835	9021
HPRD ID		05490	05006
Ensembl ID		ENSG00000120833	ENSG00000184557
Uniprot IDs		A0A024RBD2 O14508	O14543 Q6FI39
PDB IDs		2C9W 4JGH 5BO4 6I4X 6I5J 6I5N
Enriched GO Terms of Interacting Partners?
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