LIN7A and MPP7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		LIN7A	MPP7
Description		lin-7 homolog A, crumbs cell polarity complex component	MAGUK p55 scaffold protein 7
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basolateral Plasma Membrane Synapse Extracellular Exosome MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane	Nucleoplasm Adherens Junction Bicellular Tight Junction Cell Cortex Lateral Plasma Membrane Cell Junction MPP7-DLG1-LIN7 Complex
	Molecular Function	Protein Binding L27 Domain Binding	Protein Binding Protein Domain Specific Binding Signaling Adaptor Activity Cadherin Binding Molecular Adaptor Activity
	Biological Process	Exocytosis Neurotransmitter Secretion Protein Transport Maintenance Of Epithelial Cell Apical/basal Polarity Synaptic Vesicle Transport Inner Ear Development Protein-containing Complex Assembly Protein Localization To Basolateral Plasma Membrane	Establishment Of Cell Polarity Positive Regulation Of Protein-containing Complex Assembly Bicellular Tight Junction Assembly Protein Localization To Adherens Junction
Pathways		Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors	RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Age-related cataracts (age at onset) ( 25352737) Dental caries ( 23259602)	Blood protein levels ( 30072576) Bone mineral density ( 24249740) Bone mineral density (paediatric, skull) ( 24945404) Diverticular disease ( 30177863) Glaucoma (primary open-angle) ( 27001270) Heel bone mineral density ( 30598549 28869591) Hippocampal volume ( 21116278) Lumbar spine bone mineral density ( 29499414 22504420) Macular thickness ( 30535121) Obesity-related traits ( 23251661) Psychosis and Alzheimer's disease ( 22005930)
Interacting Genes		24 interacting genes: ABCA1 ADGRB1 APP BAIAP2 CASK CHRD DLG2 DLG3 DLG4 DNAJC5 ECM1 FAM9B GOLGA2 GRIN2B KCNJ12 MDFI MPP2 MPP3 MPP7 NOTCH2NLA PALS1 PALS2 SLC6A12 ZYX	7 interacting genes: DLGAP4 HSBP1 LIN7A LIN7B LIN7C MYSM1 TRIM5
Entrez ID		8825	143098
HPRD ID		04542	14733
Ensembl ID		ENSG00000111052	ENSG00000150054
Uniprot IDs		O14910	Q5T2T1
PDB IDs			3LRA 3O46
Enriched GO Terms of Interacting Partners?
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