MPP7 and LIN7A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		MPP7	LIN7A
Description		MAGUK p55 scaffold protein 7	lin-7 homolog A, crumbs cell polarity complex component
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Adherens Junction Bicellular Tight Junction Cell Cortex Lateral Plasma Membrane Cell Junction MPP7-DLG1-LIN7 Complex	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basolateral Plasma Membrane Synapse Extracellular Exosome MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane
	Molecular Function	Protein Binding Protein Domain Specific Binding Signaling Adaptor Activity Cadherin Binding Molecular Adaptor Activity	Protein Binding L27 Domain Binding
	Biological Process	Establishment Of Cell Polarity Positive Regulation Of Protein-containing Complex Assembly Bicellular Tight Junction Assembly Protein Localization To Adherens Junction	Exocytosis Neurotransmitter Secretion Protein Transport Maintenance Of Epithelial Cell Apical/basal Polarity Synaptic Vesicle Transport Inner Ear Development Protein-containing Complex Assembly Protein Localization To Basolateral Plasma Membrane
Pathways		RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle	Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Bone mineral density ( 24249740) Bone mineral density (paediatric, skull) ( 24945404) Diverticular disease ( 30177863) Glaucoma (primary open-angle) ( 27001270) Heel bone mineral density ( 30598549 28869591) Hippocampal volume ( 21116278) Lumbar spine bone mineral density ( 29499414 22504420) Macular thickness ( 30535121) Obesity-related traits ( 23251661) Psychosis and Alzheimer's disease ( 22005930)	Age-related cataracts (age at onset) ( 25352737) Dental caries ( 23259602)
Interacting Genes		7 interacting genes: DLGAP4 HSBP1 LIN7A LIN7B LIN7C MYSM1 TRIM5	24 interacting genes: ABCA1 ADGRB1 APP BAIAP2 CASK CHRD DLG2 DLG3 DLG4 DNAJC5 ECM1 FAM9B GOLGA2 GRIN2B KCNJ12 MDFI MPP2 MPP3 MPP7 NOTCH2NLA PALS1 PALS2 SLC6A12 ZYX
Entrez ID		143098	8825
HPRD ID		14733	04542
Ensembl ID		ENSG00000150054	ENSG00000111052
Uniprot IDs		Q5T2T1	O14910
PDB IDs		3LRA 3O46
Enriched GO Terms of Interacting Partners?
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