ADAM15 and NPHP1

Number of citations of the paper that reports this interaction (PubMedID 16374509)
43

Data Source:
HPRD (in vitro)

		ADAM15	NPHP1
Description		ADAM metallopeptidase domain 15	nephrocystin 1
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Space Plasma Membrane Adherens Junction Cell Surface Integral Component Of Membrane Motile Cilium Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Cell-cell Junction Adherens Junction Bicellular Tight Junction Cilium Membrane Motile Cilium Photoreceptor Connecting Cilium
	Molecular Function	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity SH3 Domain Binding Metal Ion Binding	Structural Molecule Activity Protein Binding
	Biological Process	Angiogenesis Negative Regulation Of Cell-matrix Adhesion Immune Response To Tumor Cell Proteolysis Apoptotic Process Cell-matrix Adhesion Integrin-mediated Signaling Pathway Male Gonad Development Extracellular Matrix Disassembly Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Collagen Catabolic Process Tissue Regeneration Innate Immune Response Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Receptor Binding Cellular Response To Phorbol 13-acetate 12-myristate Response To Hypobaric Hypoxia	Signal Transduction Excretion Visual Behavior Cell Projection Organization Actin Cytoskeleton Organization Spermatid Differentiation Retina Development In Camera-type Eye Protein Localization Involved In Establishment Of Planar Polarity Cell-cell Adhesion Positive Regulation Of Bicellular Tight Junction Assembly
Pathways		Degradation of the extracellular matrix Invadopodia formation	Anchoring of the basal body to the plasma membrane
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) General risk tolerance (MTAG) ( 30643258) Hip circumference adjusted for BMI ( 34021172) Mosquito bite size ( 28199695) Prostate cancer ( 23535732) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469) Walking pace ( 33128006)
Interacting Genes		36 interacting genes: ABL1 ARHGEF6 ARHGEF7 ATXN1 BANP DVL3 FHL3 FYN GRB2 HCK LCK LYN MAD2L2 NCK1 NPHP1 NUP62 ODAM PACSIN3 RBPMS SH3D19 SH3GL2 SH3GLB1 SH3PXD2A SH3RF1 SH3RF3 SNX30 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SP4 SRC TCHH TRIP13 YES1	18 interacting genes: ADAM15 ARHGAP32 BCAR1 BCL2L11 COX5B FBXO7 FLNA FLNB FLNC INVS KHDRBS1 NPHP3 NPHP4 PAK2 PTK2B TNK2 TUBB UBQLN4
Entrez ID		8751	4867
HPRD ID		05674	09524
Ensembl ID		ENSG00000143537	ENSG00000144061
Uniprot IDs		Q13444	C9JNM7 O15259
PDB IDs			1S1N 6O1Q
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?