TNK1 and GRB10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TNK1	GRB10
Description		tyrosine kinase non receptor 1	growth factor receptor bound protein 10
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Cytoplasm Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding	Insulin Receptor Binding Protein Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Differentiation Innate Immune Response Protein Autophosphorylation	Insulin Receptor Signaling Pathway Gene Expression Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphorylation Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway ERK1 And ERK2 Cascade Positive Regulation Of Cold-induced Thermogenesis Vascular Associated Smooth Muscle Cell Migration
Pathways			Signaling by SCF-KIT IRS activation Signal attenuation Insulin receptor signalling cascade RET signaling FLT3 Signaling Response of EIF2AK1 (HRI) to heme deficiency
Drugs		Fostamatinib
Diseases
GWAS			Acute lymphoblastic leukemia (childhood) ( 23512250) Area under the curve of insulin levels ( 24699409) Birth weight ( 31043758) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Corpus callosum mid-anterior volume ( 31530798) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Diastolic blood pressure ( 30224653) Eosinophil counts ( 32888494 27863252) Estimated glomerular filtration rate ( 31152163 31015462) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 33402679 34059833) Fasting insulin ( 34059833) Femoral neck bone mineral density ( 22504420) Fractures ( 30158200) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Incremental insulin ( 24699409) Insulin levels adjusted for BMI ( 24699409) Insulin-related traits (multivariate analysis) ( 32002517) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Morning person ( 30696823) Ratio of the area under the curve for insulin and the area under the curve for glucose ( 24699409) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Schizophrenia (treatment resistant) ( 25223841) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Systemic sclerosis ( 21779181) Total body bone mineral density ( 29304378) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		7 interacting genes: FAM168A GRB10 PLCG1 SAXO1 SS18L1 ZNF250 ZNF329	48 interacting genes: AANAT ABL1 AKT1 APP BAIAP2 BCR BLK CHFR CNOT9 DOK1 EGFR ELK1 EPHB1 ERBB2 ERBB4 FARS2 FYN GHR GIGYF1 GIGYF2 IGF1R INSR IRS1 JAK2 KANK2 KDR KIT KPNA3 MAP2K1 MAP3K14 MAPK1 MEGF10 NEDD4 NFKBID NOA1 PDGFRB PICK1 RAF1 RET SRC TEKT4 TEPSIN TNK1 TRIM55 TRIM63 TXK ZDHHC17 ZMYND19
Entrez ID		8711	2887
HPRD ID		09730	03312
Ensembl ID		ENSG00000174292	ENSG00000106070
Uniprot IDs		Q13470	Q13322
PDB IDs			1NRV 3HK0
Enriched GO Terms of Interacting Partners?
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