GRB10 and MAP2K1

  • Number of citations of the paper that reports this interaction (PubMedID 9553107)
  • 21
  • Data Source:
  • BioGRID (affinity chromatography technology, affinity chromatography technology)
  • HPRD (in vivo, two hybrid, in vitro)

GRB10

MAP2K1

Description growth factor receptor bound protein 10 mitogen-activated protein kinase kinase 1
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Acute lymphoblastic leukemia (childhood) ( 23512250)
  • Area under the curve of insulin levels ( 24699409)
  • Birth weight ( 31043758)
  • Blood pressure (smoking interaction) ( 25189868)
  • Body mass index ( 26426971)
  • Body mass index (age <50) ( 26426971)
  • Body mass index x sex x age interaction (4df test) ( 26426971)
  • Brain morphology (MOSTest) ( 32665545)
  • Chronotype ( 30696823)
  • Corpus callosum mid-anterior volume ( 31530798)
  • Corrected insulin response ( 24699409)
  • Corrected insulin response adjusted for insulin sensitivity index ( 24699409)
  • Diastolic blood pressure ( 30224653)
  • Eosinophil counts ( 32888494 27863252)
  • Estimated glomerular filtration rate ( 31152163 31015462)
  • Fasting blood glucose ( 22581228)
  • Fasting blood glucose (BMI interaction) ( 22581228)
  • Fasting glucose ( 33402679 34059833)
  • Fasting insulin ( 34059833)
  • Femoral neck bone mineral density ( 22504420)
  • Fractures ( 30158200)
  • Heel bone mineral density ( 30598549)
  • Hip circumference adjusted for BMI ( 34021172)
  • Incremental insulin ( 24699409)
  • Insulin levels adjusted for BMI ( 24699409)
  • Insulin-related traits (multivariate analysis) ( 32002517)
  • Mean corpuscular volume ( 32888494)
  • Mean reticulocyte volume ( 32888494)
  • Metabolite levels ( 23823483)
  • Morning person ( 30696823)
  • Ratio of the area under the curve for insulin and the area under the curve for glucose ( 24699409)
  • Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901)
  • Schizophrenia (treatment resistant) ( 25223841)
  • Subcortical volume (MOSTest) ( 32665545)
  • Sum eosinophil basophil counts ( 27863252)
  • Systemic sclerosis ( 21779181)
  • Total body bone mineral density ( 29304378)
  • Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes 48 interacting genes: AANAT ABL1 AKT1 APP BAIAP2 BCR BLK CHFR CNOT9 DOK1 EGFR ELK1 EPHB1 ERBB2 ERBB4 FARS2 FYN GHR GIGYF1 GIGYF2 IGF1R INSR IRS1 JAK2 KANK2 KDR KIT KPNA3 MAP2K1 MAP3K14 MAPK1 MEGF10 NEDD4 NFKBID NOA1 PDGFRB PICK1 RAF1 RET SRC TEKT4 TEPSIN TNK1 TRIM55 TRIM63 TXK ZDHHC17 ZMYND19 67 interacting genes: APC ARAF AURKA BANP BAX BIRC6 BMPR1A BRAF BUB1 CASP9 CDH1 CDK5 CDKN2A CPNE1 CPNE4 CTNNA1 EGFR ELK1 EP300 ERBB2 FBXW7 GRB10 HNRNPD HRAS ITCH KAT7 KSR1 KSR2 LAMTOR3 MAP3K4 MAP3K8 MAPK1 MAPK14 MAPK3 MAPK8 MAPK8IP3 MBP MLH3 MSH6 MYC ODC1 PAK1 PARVA PDGFRL PEBP1 PEBP4 PIK3CA PLEKHF2 PLK3 PPARG PRKCI PRKCZ PTPRJ RAF1 RPS6KA2 RPS6KA4 SMAD2 SRC STK11 TCP11 TGFBR2 TLR2 TRAF3 TRAF6 TRIB1 UBE2I WNK1
Entrez ID 2887 5604
HPRD ID 03312 01469
Ensembl ID ENSG00000106070 ENSG00000169032
Uniprot IDs Q13322 A4QPA9 B4DFY5 H3BRW9 Q02750
PDB IDs 1NRV 3HK0 1S9J 2P55 3DV3 3DY7 3E8N 3EQB 3EQC 3EQD 3EQF 3EQG 3EQH 3EQI 3MBL 3ORN 3OS3 3PP1 3SLS 3V01 3V04 3VVH 3W8Q 3WIG 3ZLS 3ZLW 3ZLX 3ZLY 3ZM4 4AN2 4AN3 4AN9 4ANB 4ARK 4LMN 4MNE 4U7Z 4U80 4U81 5BX0 5EYM 5HZE 5YT3 6NYB 6PP9 6Q0J 6Q0T 6U2G 6V2V 6V2W 6V2X 6V2Y 6V2Z 6V30 6V31 6V32 6X2P 6X2S 6X2X 7B3M 7B7R 7B94 7B9L
Enriched GO Terms of Interacting Partners?
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