CAMK1 and CAMKK1

Number of citations of the paper that reports this interaction (PubMedID 10187789)
21

Data Source:
HPRD (in vivo)

		CAMK1	CAMKK1
Description		calcium/calmodulin dependent protein kinase I	calcium/calmodulin dependent protein kinase kinase 1
Image
GO Annotations	Cellular Component	Intracellular Anatomical Structure Nucleus Cytosol Postsynaptic Density Glutamatergic Synapse	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Protein Serine Kinase Activity	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Nucleocytoplasmic Transport Cell Cycle Signal Transduction Nervous System Development Positive Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Cell Differentiation Negative Regulation Of Protein Binding Regulation Of Protein Localization Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Export From Nucleus Regulation Of Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Positive Regulation Of Dendritic Spine Development Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Acetylation Regulation Of Histone H3-K9 Acetylation	Protein Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity
Pathways		Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs	CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs
Drugs		Fostamatinib	Fostamatinib
Diseases
GWAS			Serum alkaline phosphatase levels ( 33339817) Smoking behavior ( 19247474)
Interacting Genes		22 interacting genes: APP ATF1 ATXN1 CALM1 CAMKK1 CAMKK2 CCND1 CDK4 CDKN1B EIF4G3 FBXO7 GAPDH GCM1 HDAC5 HSPB1 IL16 MARK2 NOS1 PIK3R3 PPME1 PPP2CA SYN1	9 interacting genes: AKT1 APP CALM1 CAMK1 CAMK1D CAMK4 PRKAA1 SGK1 YWHAG
Entrez ID		8536	84254
HPRD ID		05412	13000
Ensembl ID		ENSG00000134072	ENSG00000004660
Uniprot IDs		B0YIY3 Q14012	J3KPJ3 Q8N5S9
PDB IDs		4FG7 4FG8 4FG9 4FGB	6CCF 6CD6
Enriched GO Terms of Interacting Partners?
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