CAMK1 and ATF1

Number of citations of the paper that reports this interaction (PubMedID 8384217)
29

Data Source:
HPRD (in vitro)

		CAMK1	ATF1
Description		calcium/calmodulin dependent protein kinase I	activating transcription factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Intracellular Anatomical Structure Nucleus Cytosol Postsynaptic Density Glutamatergic Synapse	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex ATF4-CREB1 Transcription Factor Complex ATF1-ATF4 Transcription Factor Complex
	Molecular Function	Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Protein Serine Kinase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein-containing Complex Binding Protein Heterodimerization Activity
	Biological Process	Protein Phosphorylation Nucleocytoplasmic Transport Cell Cycle Signal Transduction Nervous System Development Positive Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Cell Differentiation Negative Regulation Of Protein Binding Regulation Of Protein Localization Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Export From Nucleus Regulation Of Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Positive Regulation Of Dendritic Spine Development Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Acetylation Regulation Of Histone H3-K9 Acetylation	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Projection Development Response To Organic Cyclic Compound Response To Cobalt Ion Cellular Protein-containing Complex Assembly Positive Regulation Of DNA Replication Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs	CREB phosphorylation NGF-stimulated transcription NGF-stimulated transcription
Drugs		Fostamatinib	Pseudoephedrine
Diseases
GWAS			Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Colorectal cancer ( 25990418 20972440 24737748) Colorectal cancer or advanced adenoma ( 30510241) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) HDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Male-pattern baldness ( 27182965) Mean arterial pressure ( 27618448) Multiple sclerosis ( 31604244) Spleen volume ( 34128465) Sudden cardiac arrest ( 21658281) Systolic blood pressure ( 30578418)
Interacting Genes		22 interacting genes: APP ATF1 ATXN1 CALM1 CAMKK1 CAMKK2 CCND1 CDK4 CDKN1B EIF4G3 FBXO7 GAPDH GCM1 HDAC5 HSPB1 IL16 MARK2 NOS1 PIK3R3 PPME1 PPP2CA SYN1	23 interacting genes: BRCA1 CAMK1 CAMK2A CAMK2G CREB1 CREBBP CREM CSNK2A1 CSNK2A2 CSNK2B DNMT3L EDF1 GABPA GABPB1 HNF1B JUN MAPKAPK2 MAPKAPK3 PRKACA RPS6KA4 RPS6KA5 SPI1 SRA1
Entrez ID		8536	466
HPRD ID		05412	00440
Ensembl ID		ENSG00000134072	ENSG00000123268
Uniprot IDs		B0YIY3 Q14012	P18846
PDB IDs		4FG7 4FG8 4FG9 4FGB
Enriched GO Terms of Interacting Partners?
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