RSPO3 and ZNRF3

Number of citations of the paper that reports this interaction (PubMedID 29752411)
20

Data Source:
BioGRID (fluorescent resonance energy transfer, pull down, pull down)

		RSPO3	ZNRF3
Description		R-spondin 3	zinc and ring finger 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Signaling Receptor Binding Frizzled Binding Heparin Binding	Ubiquitin-protein Transferase Activity Frizzled Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Blood Vessel Remodeling Sprouting Angiogenesis Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Non-canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	Ubiquitin-dependent Protein Catabolic Process Wnt Signaling Pathway Protein Ubiquitination Wnt Receptor Catabolic Process Limb Development Stem Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		Regulation of FZD by ubiquitination RUNX1 regulates transcription of genes involved in WNT signaling	Regulation of FZD by ubiquitination
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301 34315874) Blood pressure ( 23972371) Blood protein levels ( 30072576 29875488) Blood urea nitrogen levels ( 31152163 29403010) Body shape index ( 34021172) Bone mineral density ( 21533022) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) Bone mineral density (spine) ( 26733130) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cleft lip with or without cleft palate x maternal periconceptional vitamin use interaction (parent of origin effect) ( 31372216) Cortical surface area ( 32963231) Cortical volume ( 32963231) Crohn's disease ( 28067908) Diastolic blood pressure ( 27841878 29403010 28739976 27618452 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fasting insulin ( 33402679 34059833) Femoral neck bone mineral density ( 29499414 22504420) Food addiction ( 27106561) Fractures ( 30158200 30598549) HDL cholesterol ( 24097068 30275531) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Heel bone mineral density ( 30598549 30048462 28869591) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 33339817) Hip circumference ( 31453325) Hip circumference adjusted for BMI ( 34021172 25673412) Hip circumference variance ( 31453325) Hip index ( 34021172) Intracranial volume ( 22504418) Iron status biomarkers ( 19084217) LDL cholesterol levels ( 32203549) LDL cholesterol levels in HIV infection ( 33109212) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Liver volume ( 34128465) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FVC) ( 30061609) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 27182965) Mean arterial pressure ( 29403010 30487518) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (HMG CoA reductase inhibitors) ( 31015401) Menarche (age at onset) ( 27182965) Metabolic syndrome ( 31589552) Metabolite levels ( 21909109) Monobrow ( 27182965) Neutrophil percentage of white cells ( 32888494) Occipital lobe volume ( 31396565) Optic disc size ( 31809533) Pancreas volume ( 34128465) Pulse pressure ( 27841878) QT interval ( 29213071) Red blood cell count ( 32888494 27863252) Renal function-related traits (BUN) ( 22797727) Serum urea levels ( 30808845) Subcortical brain region volumes ( 25607358) Systolic blood pressure ( 27841878 28739976 27618452 30487518) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Triglyceride levels ( 32203549 28334899 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 24097068 25961943) Waist circumference ( 25673412) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 34021172 25673412 28448500) Waist-hip index ( 34021172) Waist-hip ratio ( 28552196 23563607 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 28552196 34021172 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28270201 25673412 28448500)	Body shape index ( 34021172) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Diastolic blood pressure ( 27618448 30487518) Gut microbiota (bacterial taxa) ( 27694959) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 29403010 27618448 30487518) Neutrophil percentage of white cells ( 32888494) Pancreatic cancer ( 29422604 25086665) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure ( 27618448 30578418) Type 2 diabetes ( 32499647) Waist circumference adjusted for body mass index ( 34021172 25673412) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: HRAS LGR4 MTDH ZNRF3	8 interacting genes: C3orf52 GFI1B HOXA1 HSPB1 RSPO1 RSPO2 RSPO3 UBE2N
Entrez ID		84870	84133
HPRD ID		18181	11737
Ensembl ID		ENSG00000146374	ENSG00000183579
Uniprot IDs		Q9BXY4	A0A024R1J1 Q9ULT6
PDB IDs
Enriched GO Terms of Interacting Partners?
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