RSPO3 and LGR4

Number of citations of the paper that reports this interaction (PubMedID 29752411)
20

Data Source:
BioGRID (pull down, pull down, fluorescent resonance energy transfer)

		RSPO3	LGR4
Description		R-spondin 3	leucine rich repeat containing G protein-coupled receptor 4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Signaling Receptor Binding Frizzled Binding Heparin Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity
	Biological Process	Blood Vessel Remodeling Sprouting Angiogenesis Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Non-canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	Osteoblast Differentiation Negative Regulation Of Cytokine Production Hair Follicle Development Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Spermatogenesis Hormone-mediated Signaling Pathway Bone Mineralization Male Genitalia Development Circadian Regulation Of Gene Expression Negative Regulation Of Toll-like Receptor Signaling Pathway Intestinal Stem Cell Homeostasis Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Bone Remodeling Digestive Tract Development Canonical Wnt Signaling Pathway Involved In Metanephric Kidney Development Cell Differentiation Involved In Metanephros Development Metanephric Glomerulus Development Metanephric Nephron Tubule Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis
Pathways		Regulation of FZD by ubiquitination RUNX1 regulates transcription of genes involved in WNT signaling	Regulation of FZD by ubiquitination
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301 34315874) Blood pressure ( 23972371) Blood protein levels ( 30072576 29875488) Blood urea nitrogen levels ( 31152163 29403010) Body shape index ( 34021172) Bone mineral density ( 21533022) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) Bone mineral density (spine) ( 26733130) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cleft lip with or without cleft palate x maternal periconceptional vitamin use interaction (parent of origin effect) ( 31372216) Cortical surface area ( 32963231) Cortical volume ( 32963231) Crohn's disease ( 28067908) Diastolic blood pressure ( 27841878 29403010 28739976 27618452 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fasting insulin ( 33402679 34059833) Femoral neck bone mineral density ( 29499414 22504420) Food addiction ( 27106561) Fractures ( 30158200 30598549) HDL cholesterol ( 24097068 30275531) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Heel bone mineral density ( 30598549 30048462 28869591) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 33339817) Hip circumference ( 31453325) Hip circumference adjusted for BMI ( 34021172 25673412) Hip circumference variance ( 31453325) Hip index ( 34021172) Intracranial volume ( 22504418) Iron status biomarkers ( 19084217) LDL cholesterol levels ( 32203549) LDL cholesterol levels in HIV infection ( 33109212) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Liver volume ( 34128465) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FVC) ( 30061609) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 27182965) Mean arterial pressure ( 29403010 30487518) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (HMG CoA reductase inhibitors) ( 31015401) Menarche (age at onset) ( 27182965) Metabolic syndrome ( 31589552) Metabolite levels ( 21909109) Monobrow ( 27182965) Neutrophil percentage of white cells ( 32888494) Occipital lobe volume ( 31396565) Optic disc size ( 31809533) Pancreas volume ( 34128465) Pulse pressure ( 27841878) QT interval ( 29213071) Red blood cell count ( 32888494 27863252) Renal function-related traits (BUN) ( 22797727) Serum urea levels ( 30808845) Subcortical brain region volumes ( 25607358) Systolic blood pressure ( 27841878 28739976 27618452 30487518) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Triglyceride levels ( 32203549 28334899 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 24097068 25961943) Waist circumference ( 25673412) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 34021172 25673412 28448500) Waist-hip index ( 34021172) Waist-hip ratio ( 28552196 23563607 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 28552196 34021172 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28270201 25673412 28448500)	Blond vs. brown/black hair color ( 30531825) Bone mineral density ( 23644456) Bone mineral density (paediatric, skull) ( 24945404) Brain morphology (MOSTest) ( 32665545) Dental caries (decayed, missing and filled teeth) ( 31533690) Heel bone mineral density ( 30598549) Male-pattern baldness ( 28196072) Menarche (age at onset) ( 25231870) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Survival in pancreatic cancer ( 28470677) Urate levels in obese individuals ( 25811787)
Interacting Genes		4 interacting genes: HRAS LGR4 MTDH ZNRF3	5 interacting genes: MARCHF2 RSPO1 RSPO2 RSPO3 RSPO4
Entrez ID		84870	55366
HPRD ID		18181	05978
Ensembl ID		ENSG00000146374	ENSG00000205213
Uniprot IDs		Q9BXY4	Q59ER8 Q9BXB1
PDB IDs			4KT1 4QXE 4QXF
Enriched GO Terms of Interacting Partners?
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