RSPO3 and HRAS

  • Number of citations of the paper that reports this interaction (PubMedID 30655611)
  • 7
  • Data Source:
  • BioGRID (pull down, affinity chromatography technology)

RSPO3

HRAS

Description R-spondin 3 HRas proto-oncogene, GTPase
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Alanine aminotransferase levels ( 34315874)
  • Apolipoprotein A1 levels ( 32203549)
  • Apolipoprotein B levels ( 32203549)
  • Aspartate aminotransferase levels ( 33547301 34315874)
  • Blood pressure ( 23972371)
  • Blood protein levels ( 30072576 29875488)
  • Blood urea nitrogen levels ( 31152163 29403010)
  • Body shape index ( 34021172)
  • Bone mineral density ( 21533022)
  • Bone mineral density (paediatric, skull) ( 24945404)
  • Bone mineral density (paediatric, total body less head) ( 24945404)
  • Bone mineral density (paediatric, upper limb) ( 24945404)
  • Bone mineral density (spine) ( 26733130)
  • Bone properties (heel) ( 24430505)
  • Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463)
  • Bone ultrasound measurement (velocity of sound) ( 28472463)
  • C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809)
  • Cleft lip with or without cleft palate x maternal periconceptional vitamin use interaction (parent of origin effect) ( 31372216)
  • Cortical surface area ( 32963231)
  • Cortical volume ( 32963231)
  • Crohn's disease ( 28067908)
  • Diastolic blood pressure ( 27841878 29403010 28739976 27618452 30487518)
  • Diastolic blood pressure (cigarette smoking interaction) ( 29455858)
  • Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
  • Fasting insulin ( 33402679 34059833)
  • Femoral neck bone mineral density ( 29499414 22504420)
  • Food addiction ( 27106561)
  • Fractures ( 30158200 30598549)
  • HDL cholesterol ( 24097068 30275531)
  • HDL cholesterol levels ( 32203549 28334899 30698716)
  • HDL cholesterol levels in current drinkers ( 30698716)
  • HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
  • HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535)
  • HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
  • Heel bone mineral density ( 30598549 30048462 28869591)
  • Hematocrit ( 32888494)
  • Hemoglobin ( 32888494)
  • Hemoglobin concentration ( 27863252)
  • Hemoglobin levels ( 32327693)
  • High density lipoprotein cholesterol levels ( 33339817)
  • Hip circumference ( 31453325)
  • Hip circumference adjusted for BMI ( 34021172 25673412)
  • Hip circumference variance ( 31453325)
  • Hip index ( 34021172)
  • Intracranial volume ( 22504418)
  • Iron status biomarkers ( 19084217)
  • LDL cholesterol levels ( 32203549)
  • LDL cholesterol levels in HIV infection ( 33109212)
  • Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)
  • Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025)
  • Liver volume ( 34128465)
  • Low density lipoprotein cholesterol levels ( 32154731)
  • Lung function (FVC) ( 30061609)
  • Lymphocyte counts ( 32888494)
  • Lymphocyte percentage of white cells ( 32888494)
  • Male-pattern baldness ( 27182965)
  • Mean arterial pressure ( 29403010 30487518)
  • Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Medication use (HMG CoA reductase inhibitors) ( 31015401)
  • Menarche (age at onset) ( 27182965)
  • Metabolic syndrome ( 31589552)
  • Metabolite levels ( 21909109)
  • Monobrow ( 27182965)
  • Neutrophil percentage of white cells ( 32888494)
  • Occipital lobe volume ( 31396565)
  • Optic disc size ( 31809533)
  • Pancreas volume ( 34128465)
  • Pulse pressure ( 27841878)
  • QT interval ( 29213071)
  • Red blood cell count ( 32888494 27863252)
  • Renal function-related traits (BUN) ( 22797727)
  • Serum urea levels ( 30808845)
  • Subcortical brain region volumes ( 25607358)
  • Systolic blood pressure ( 27841878 28739976 27618452 30487518)
  • Systolic blood pressure (cigarette smoking interaction) ( 29455858)
  • Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Triglyceride levels ( 32203549 28334899 32154731)
  • Triglyceride levels in current drinkers ( 30698716)
  • Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
  • Triglycerides ( 24097068 25961943)
  • Waist circumference ( 25673412)
  • Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500)
  • Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
  • Waist circumference adjusted for BMI in active individuals ( 28448500)
  • Waist circumference adjusted for BMI in non-smokers ( 28443625)
  • Waist circumference adjusted for body mass index ( 28552196 34021172 25673412 28448500)
  • Waist-hip index ( 34021172)
  • Waist-hip ratio ( 28552196 23563607 25673412 20935629)
  • Waist-to-hip ratio adjusted for BMI ( 28552196 34021172 26426971)
  • Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
  • Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971)
  • Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500)
  • Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
  • Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500)
  • Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625)
  • Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
  • Waist-to-hip ratio adjusted for body mass index ( 28270201 25673412 28448500)
Interacting Genes 4 interacting genes: HRAS LGR4 MTDH ZNRF3 153 interacting genes: ABR ACTG1 AFDN AGTR1 ANAPC1 ANKRD11 ANKRD16 ANKRD23 ANKRD34B APBB1IP ARAF ARFGAP1 ARHGAP10 ARHGAP29 ARHGEF1 ARHGEF18 BCL2 BLID BMPR1A BRAF BRAP BUB1 C6orf62 CAV1 CCL4 CDC123 CDC25A CDC25C CDH1 CDKN2A CTNNA1 CXCL1 DEAF1 DGKE DGKZ DPP9 EIF3L ERBB2 FBXW7 FNTA FNTB FYN GPSM2 GPSM3 GRB2 GREB1 GRIN1 GRIN2D HBG1 HECTD1 HSPA12A HSPA1L ICMT IGF2 IKZF3 IL1RL1 IL24 IL3 INS INSR IRAK1 IRAK2 ITGB3 ITSN1 KCNQ1 KRAS KRT17 KRT18 LGALS1 LZTR1 MAP2K1 MAP2K6 MAP3K6 MAPK10 MAPK8 MLH3 MSH2 MSH6 MTOR MUTYH NF1 NRAS PDE4D PDE6D PDGFB PDGFRL PI4K2A PIK3CA PIK3CD PIK3CG PIK3R1 PLA2G4B PLAAT4 PLCE1 PLCH2 PRKCI PRKCZ PRSS50 PTPRJ QPCT RAB5C RABAC1 RABGEF1 RAF1 RALGDS RAP1B RAP1GDS1 RAPGEF1 RASA1 RASA2 RASA4 RASGRF1 RASGRP1 RASGRP4 RASIP1 RASSF1 RASSF2 RASSF5 RGL1 RGL2 RGL4 RGS12 RHOD RIN1 RIT2 RNF115 RSPO3 SHOC2 SMAD4 SNRPE SNX14 SNX17 SOS1 SOS2 SRC STK11 STK38 TIAM1 TLR2 TLR6 TLR9 TP73 TTC1 TTC21A TTC28 UBE3B UBE4B USP29 USP42 VAV1 ZBTB10 ZBTB12 ZFP36L2
Entrez ID 84870 3265
HPRD ID 18181 01813
Ensembl ID ENSG00000146374 ENSG00000174775
Uniprot IDs Q9BXY4 P01112 X5D945
PDB IDs 121P 1AA9 1AGP 1BKD 1CLU 1CRP 1CRQ 1CRR 1CTQ 1GNP 1GNQ 1GNR 1HE8 1IAQ 1IOZ 1JAH 1JAI 1K8R 1LF0 1LF5 1LFD 1NVU 1NVV 1NVW 1NVX 1P2S 1P2T 1P2U 1P2V 1PLJ 1PLK 1PLL 1Q21 1QRA 1RVD 1WQ1 1XCM 1XD2 1XJ0 1ZVQ 1ZW6 221P 2C5L 2CE2 2CL0 2CL6 2CL7 2CLC 2CLD 2EVW 2GDP 2LCF 2LWI 2N42 2N46 2Q21 2QUZ 2RGA 2RGB 2RGC 2RGD 2RGE 2RGG 2UZI 2VH5 2X1V 3DDC 3I3S 3K8Y 3K9L 3K9N 3KKM 3KKN 3KUD 3L8Y 3L8Z 3LBH 3LBI 3LBN 3LO5 3OIU 3OIV 3OIW 3RRY 3RRZ 3RS0 3RS2 3RS3 3RS4 3RS5 3RS7 3RSL 3RSO 3TGP 421P 4DLR 4DLS 4DLT 4DLU 4DLV 4DLW 4DLX 4DLY 4DLZ 4DST 4DSU 4EFL 4EFM 4EFN 4G0N 4G3X 4K81 4L9S 4L9W 4NYI 4NYJ 4NYM 4Q21 4RSG 4URU 4URV 4URW 4URX 4URY 4URZ 4US0 4US1 4US2 4XVQ 4XVR 521P 5B2Z 5B30 5E95 5P21 5VBE 5VBZ 5WDO 5WDP 5WDQ 5WFO 5WFP 5WFQ 5WFR 5WPL 5X9S 5ZC6 621P 6AMB 6AXG 6BVI 6BVJ 6BVK 6BVL 6BVM 6CUO 6CUP 6CUR 6D55 6D56 6D59 6D5E 6D5G 6D5H 6D5J 6D5L 6D5M 6D5V 6D5W 6DZH 6E6C 6E6P 6MQT 6NTC 6NTD 6Q21 6V94 6V9F 6V9J 6V9L 6V9M 6V9N 6V9O 6ZJ0 6ZL3 721P 7JHP 821P
Enriched GO Terms of Interacting Partners?
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