Description |
R-spondin 3 |
HRas proto-oncogene, GTPase |
Image |
No pdb structure |
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GO Annotations |
Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
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Diseases |
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GWAS |
- Alanine aminotransferase levels ( 34315874)
- Apolipoprotein A1 levels ( 32203549)
- Apolipoprotein B levels ( 32203549)
- Aspartate aminotransferase levels ( 33547301 34315874)
- Blood pressure ( 23972371)
- Blood protein levels ( 30072576 29875488)
- Blood urea nitrogen levels ( 31152163 29403010)
- Body shape index ( 34021172)
- Bone mineral density ( 21533022)
- Bone mineral density (paediatric, skull) ( 24945404)
- Bone mineral density (paediatric, total body less head) ( 24945404)
- Bone mineral density (paediatric, upper limb) ( 24945404)
- Bone mineral density (spine) ( 26733130)
- Bone properties (heel) ( 24430505)
- Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463)
- Bone ultrasound measurement (velocity of sound) ( 28472463)
- C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809)
- Cleft lip with or without cleft palate x maternal periconceptional vitamin use interaction (parent of origin effect) ( 31372216)
- Cortical surface area ( 32963231)
- Cortical volume ( 32963231)
- Crohn's disease ( 28067908)
- Diastolic blood pressure ( 27841878 29403010 28739976 27618452 30487518)
- Diastolic blood pressure (cigarette smoking interaction) ( 29455858)
- Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
- Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
- Fasting insulin ( 33402679 34059833)
- Femoral neck bone mineral density ( 29499414 22504420)
- Food addiction ( 27106561)
- Fractures ( 30158200 30598549)
- HDL cholesterol ( 24097068 30275531)
- HDL cholesterol levels ( 32203549 28334899 30698716)
- HDL cholesterol levels in current drinkers ( 30698716)
- HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
- HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
- HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535)
- HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
- Heel bone mineral density ( 30598549 30048462 28869591)
- Hematocrit ( 32888494)
- Hemoglobin ( 32888494)
- Hemoglobin concentration ( 27863252)
- Hemoglobin levels ( 32327693)
- High density lipoprotein cholesterol levels ( 33339817)
- Hip circumference ( 31453325)
- Hip circumference adjusted for BMI ( 34021172 25673412)
- Hip circumference variance ( 31453325)
- Hip index ( 34021172)
- Intracranial volume ( 22504418)
- Iron status biomarkers ( 19084217)
- LDL cholesterol levels ( 32203549)
- LDL cholesterol levels in HIV infection ( 33109212)
- Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)
- Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025)
- Liver volume ( 34128465)
- Low density lipoprotein cholesterol levels ( 32154731)
- Lung function (FVC) ( 30061609)
- Lymphocyte counts ( 32888494)
- Lymphocyte percentage of white cells ( 32888494)
- Male-pattern baldness ( 27182965)
- Mean arterial pressure ( 29403010 30487518)
- Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962)
- Medication use (HMG CoA reductase inhibitors) ( 31015401)
- Menarche (age at onset) ( 27182965)
- Metabolic syndrome ( 31589552)
- Metabolite levels ( 21909109)
- Monobrow ( 27182965)
- Neutrophil percentage of white cells ( 32888494)
- Occipital lobe volume ( 31396565)
- Optic disc size ( 31809533)
- Pancreas volume ( 34128465)
- Pulse pressure ( 27841878)
- QT interval ( 29213071)
- Red blood cell count ( 32888494 27863252)
- Renal function-related traits (BUN) ( 22797727)
- Serum urea levels ( 30808845)
- Subcortical brain region volumes ( 25607358)
- Systolic blood pressure ( 27841878 28739976 27618452 30487518)
- Systolic blood pressure (cigarette smoking interaction) ( 29455858)
- Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
- Triglyceride levels ( 32203549 28334899 32154731)
- Triglyceride levels in current drinkers ( 30698716)
- Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
- Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
- Triglycerides ( 24097068 25961943)
- Waist circumference ( 25673412)
- Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
- Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500)
- Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
- Waist circumference adjusted for BMI in active individuals ( 28448500)
- Waist circumference adjusted for BMI in non-smokers ( 28443625)
- Waist circumference adjusted for body mass index ( 28552196 34021172 25673412 28448500)
- Waist-hip index ( 34021172)
- Waist-hip ratio ( 28552196 23563607 25673412 20935629)
- Waist-to-hip ratio adjusted for BMI ( 28552196 34021172 26426971)
- Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
- Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
- Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971)
- Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500)
- Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
- Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500)
- Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625)
- Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
- Waist-to-hip ratio adjusted for body mass index ( 28270201 25673412 28448500)
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Interacting Genes |
4 interacting genes:
HRAS
LGR4
MTDH
ZNRF3
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153 interacting genes:
ABR
ACTG1
AFDN
AGTR1
ANAPC1
ANKRD11
ANKRD16
ANKRD23
ANKRD34B
APBB1IP
ARAF
ARFGAP1
ARHGAP10
ARHGAP29
ARHGEF1
ARHGEF18
BCL2
BLID
BMPR1A
BRAF
BRAP
BUB1
C6orf62
CAV1
CCL4
CDC123
CDC25A
CDC25C
CDH1
CDKN2A
CTNNA1
CXCL1
DEAF1
DGKE
DGKZ
DPP9
EIF3L
ERBB2
FBXW7
FNTA
FNTB
FYN
GPSM2
GPSM3
GRB2
GREB1
GRIN1
GRIN2D
HBG1
HECTD1
HSPA12A
HSPA1L
ICMT
IGF2
IKZF3
IL1RL1
IL24
IL3
INS
INSR
IRAK1
IRAK2
ITGB3
ITSN1
KCNQ1
KRAS
KRT17
KRT18
LGALS1
LZTR1
MAP2K1
MAP2K6
MAP3K6
MAPK10
MAPK8
MLH3
MSH2
MSH6
MTOR
MUTYH
NF1
NRAS
PDE4D
PDE6D
PDGFB
PDGFRL
PI4K2A
PIK3CA
PIK3CD
PIK3CG
PIK3R1
PLA2G4B
PLAAT4
PLCE1
PLCH2
PRKCI
PRKCZ
PRSS50
PTPRJ
QPCT
RAB5C
RABAC1
RABGEF1
RAF1
RALGDS
RAP1B
RAP1GDS1
RAPGEF1
RASA1
RASA2
RASA4
RASGRF1
RASGRP1
RASGRP4
RASIP1
RASSF1
RASSF2
RASSF5
RGL1
RGL2
RGL4
RGS12
RHOD
RIN1
RIT2
RNF115
RSPO3
SHOC2
SMAD4
SNRPE
SNX14
SNX17
SOS1
SOS2
SRC
STK11
STK38
TIAM1
TLR2
TLR6
TLR9
TP73
TTC1
TTC21A
TTC28
UBE3B
UBE4B
USP29
USP42
VAV1
ZBTB10
ZBTB12
ZFP36L2
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Entrez ID |
84870 |
3265 |
HPRD ID |
18181 |
01813 |
Ensembl ID |
ENSG00000146374
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ENSG00000174775
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Uniprot IDs |
Q9BXY4
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P01112
X5D945
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PDB IDs |
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121P
1AA9
1AGP
1BKD
1CLU
1CRP
1CRQ
1CRR
1CTQ
1GNP
1GNQ
1GNR
1HE8
1IAQ
1IOZ
1JAH
1JAI
1K8R
1LF0
1LF5
1LFD
1NVU
1NVV
1NVW
1NVX
1P2S
1P2T
1P2U
1P2V
1PLJ
1PLK
1PLL
1Q21
1QRA
1RVD
1WQ1
1XCM
1XD2
1XJ0
1ZVQ
1ZW6
221P
2C5L
2CE2
2CL0
2CL6
2CL7
2CLC
2CLD
2EVW
2GDP
2LCF
2LWI
2N42
2N46
2Q21
2QUZ
2RGA
2RGB
2RGC
2RGD
2RGE
2RGG
2UZI
2VH5
2X1V
3DDC
3I3S
3K8Y
3K9L
3K9N
3KKM
3KKN
3KUD
3L8Y
3L8Z
3LBH
3LBI
3LBN
3LO5
3OIU
3OIV
3OIW
3RRY
3RRZ
3RS0
3RS2
3RS3
3RS4
3RS5
3RS7
3RSL
3RSO
3TGP
421P
4DLR
4DLS
4DLT
4DLU
4DLV
4DLW
4DLX
4DLY
4DLZ
4DST
4DSU
4EFL
4EFM
4EFN
4G0N
4G3X
4K81
4L9S
4L9W
4NYI
4NYJ
4NYM
4Q21
4RSG
4URU
4URV
4URW
4URX
4URY
4URZ
4US0
4US1
4US2
4XVQ
4XVR
521P
5B2Z
5B30
5E95
5P21
5VBE
5VBZ
5WDO
5WDP
5WDQ
5WFO
5WFP
5WFQ
5WFR
5WPL
5X9S
5ZC6
621P
6AMB
6AXG
6BVI
6BVJ
6BVK
6BVL
6BVM
6CUO
6CUP
6CUR
6D55
6D56
6D59
6D5E
6D5G
6D5H
6D5J
6D5L
6D5M
6D5V
6D5W
6DZH
6E6C
6E6P
6MQT
6NTC
6NTD
6Q21
6V94
6V9F
6V9J
6V9L
6V9M
6V9N
6V9O
6ZJ0
6ZL3
721P
7JHP
821P
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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