CAT and EHHADH

Number of citations of the paper that reports this interaction (PubMedID 29568061)
40

Data Source:
BioGRID (proximity labelling technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology)

		CAT	EHHADH
Description		catalase	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Lysosome Peroxisome Peroxisomal Membrane Peroxisomal Matrix Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Membrane Protein-containing Complex Secretory Granule Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Ficolin-1-rich Granule Lumen	Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	Peroxisome Targeting Sequence Binding Aminoacylase Activity Catalase Activity Antioxidant Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Enzyme Binding Heme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding NADP Binding	3-hydroxyacyl-CoA Dehydrogenase Activity Dodecenoyl-CoA Delta-isomerase Activity Enoyl-CoA Hydratase Activity Protein Binding Long-chain-enoyl-CoA Hydratase Activity Long-chain-3-hydroxyacyl-CoA Dehydrogenase Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Enzyme Binding NAD+ Binding
	Biological Process	Response To Reactive Oxygen Species Osteoblast Differentiation Ureteric Bud Development Response To Hypoxia Triglyceride Metabolic Process Aging Cholesterol Metabolic Process Aerobic Respiration Response To Xenobiotic Stimulus Response To Light Intensity UV Protection Response To Ozone Response To Lead Ion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Activity Response To Inactivity Hemoglobin Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Estradiol Response To Insulin Response To Vitamin A Response To Vitamin E Response To L-ascorbic Acid Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Response To Ethanol Response To Cadmium Ion Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cell Division Response To Hyperoxia Response To Fatty Acid Cellular Response To Growth Factor Stimulus Response To Phenylpropanoid Cellular Oxidant Detoxification	Fatty Acid Beta-oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase
Pathways		Detoxification of Reactive Oxygen Species Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import
Drugs		Fomepizole Cannabidiol Medical Cannabis Nabiximols	NADH
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269)	Cognitive performance ( 19734545) Major depressive disorder ( 27519822 21042317)
Interacting Genes		11 interacting genes: ABL1 ABL2 APP CD44 EHHADH KEAP1 OGT PRKRA PTPN11 SUMO4 TLR10	100 interacting genes: AARS2 ACTB ACTG1 ADARB1 ANKRD36B ARMC12 ARMCX3 BHLHE40 BOLL CAT CBS CCDC102B CCDC13 CDR2L CEP83 CISD2 CLDN18 CLDN5 CLK2 CMTM6 COQ9 CYB561 CYB561A3 DAAM2 DERL3 DES EMP1 ERGIC1 FGF14 FUNDC1 GAS8 GMCL1 GRIPAP1 HID1 HIP1 HSD17B11 HTATIP2 JAGN1 KCTD6 KCTD9 KRTAP10-7 KRTAP4-11 LCN2 LEPROTL1 LYPD5 LZTFL1 LZTS2 MAB21L3 MID1 MTUS2 NACC1 NECAB2 OPRM1 ORMDL1 PAQR8 PICK1 PNMA1 PNMA5 PPP1R12C PRKRA PSTPIP1 PTGES REL RNF4 RPRM RUSF1 SCARA5 SCP2 SDR16C5 SGCB SLC14A2 SLC39A2 SMIM5 SMN1 SMN2 SSNA1 SSX2IP SYNGR3 TMEM121 TMEM17 TMEM31 TMEM35A TNIP1 TPP2 TRAF1 TRIM21 TRIM23 TRIM27 TRIM41 TRIM5 TRIM54 TRIM55 TRIM63 VAC14 ZBTB10 ZBTB26 ZBTB8A ZBTB9 ZCCHC17 ZRANB1
Entrez ID		847	1962
HPRD ID		00282	06125
Ensembl ID		ENSG00000121691	ENSG00000113790
Uniprot IDs		A0A384P5Q0 P04040	Q08426
PDB IDs		1DGB 1DGF 1DGG 1DGH 1F4J 1QQW
Enriched GO Terms of Interacting Partners?
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