CCDC115 and ALOX15B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CCDC115	ALOX15B
Description		coiled-coil domain containing 115	arachidonate 15-lipoxygenase type B
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Vacuolar Proton-transporting V-type ATPase Complex COPI-coated Vesicle Extrinsic Component Of Endoplasmic Reticulum Membrane	Nucleus Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Membrane Extrinsic Component Of Membrane Extracellular Exosome
	Molecular Function	Protein Binding Unfolded Protein Binding	Iron Ion Binding Calcium Ion Binding Protein Binding Lipid Binding Linoleate 13S-lipoxygenase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Arachidonate 8(S)-lipoxygenase Activity Arachidonate 15-lipoxygenase Activity Linoleate 9S-lipoxygenase Activity
	Biological Process	Cellular Iron Ion Homeostasis Lysosomal Lumen Acidification Cellular Response To Increased Oxygen Levels Vacuolar Proton-transporting V-type ATPase Complex Assembly Lysosomal Protein Catabolic Process	Lipid Metabolic Process Phospholipid Metabolic Process Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Arachidonic Acid Metabolic Process Lipoxygenase Pathway Negative Regulation Of Cell Migration Prostate Gland Development Regulation Of Epithelial Cell Differentiation Positive Regulation Of Chemokine Production Lipid Oxidation Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Linoleic Acid Metabolic Process Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of Growth Hepoxilin Biosynthetic Process Endocannabinoid Signaling Pathway Cannabinoid Biosynthetic Process Lipoxin A4 Biosynthetic Process
Pathways		RHOA GTPase cycle	Synthesis of 15-eicosatetraenoic acid derivatives
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483)
Interacting Genes		10 interacting genes: ABI2 ALOX15B APP CSNK2B MIS18A NTAQ1 PLK1 PRKCZ RARS1 TK1	9 interacting genes: CCDC115 CTAG1A CTAG1B KCNF1 PPARG RARA RXRA TRAIP TRIM21
Entrez ID		84317	247
HPRD ID		14428	04739
Ensembl ID		ENSG00000136710	ENSG00000179593
Uniprot IDs		A1QKJ6 B8ZZ99 Q96NT0	O15296
PDB IDs			4NRE
Enriched GO Terms of Interacting Partners?
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