ALOX15B and KCNF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ALOX15B	KCNF1
Description		arachidonate 15-lipoxygenase type B	potassium voltage-gated channel modifier subfamily F member 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Membrane Extrinsic Component Of Membrane Extracellular Exosome	Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane
	Molecular Function	Iron Ion Binding Calcium Ion Binding Protein Binding Lipid Binding Linoleate 13S-lipoxygenase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Arachidonate 8(S)-lipoxygenase Activity Arachidonate 15-lipoxygenase Activity Linoleate 9S-lipoxygenase Activity	Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Arachidonic Acid Metabolic Process Lipoxygenase Pathway Negative Regulation Of Cell Migration Prostate Gland Development Regulation Of Epithelial Cell Differentiation Positive Regulation Of Chemokine Production Lipid Oxidation Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Linoleic Acid Metabolic Process Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of Growth Hepoxilin Biosynthetic Process Endocannabinoid Signaling Pathway Cannabinoid Biosynthetic Process Lipoxin A4 Biosynthetic Process	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Protein Homooligomerization Potassium Ion Transmembrane Transport
Pathways		Synthesis of 15-eicosatetraenoic acid derivatives	Voltage gated Potassium channels
Drugs			Enflurane Promethazine Miconazole
Diseases
GWAS		Blood protein levels ( 30072576) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: CCDC115 CTAG1A CTAG1B KCNF1 PPARG RARA RXRA TRAIP TRIM21	13 interacting genes: ALOX15B CLPTM1L FARS2 KCNG3 KCNG4 KCNH1 KCNV2 MCL1 OPRM1 SERP1 SLC39A7 TCEA2 TSPO
Entrez ID		247	3754
HPRD ID		04739	04808
Ensembl ID		ENSG00000179593	ENSG00000162975
Uniprot IDs		O15296	Q9H3M0
PDB IDs		4NRE
Enriched GO Terms of Interacting Partners?
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