ALOX15B and CCDC115

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ALOX15B	CCDC115
Description		arachidonate 15-lipoxygenase type B	coiled-coil domain containing 115
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Membrane Extrinsic Component Of Membrane Extracellular Exosome	Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Vacuolar Proton-transporting V-type ATPase Complex COPI-coated Vesicle Extrinsic Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Iron Ion Binding Calcium Ion Binding Protein Binding Lipid Binding Linoleate 13S-lipoxygenase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Arachidonate 8(S)-lipoxygenase Activity Arachidonate 15-lipoxygenase Activity Linoleate 9S-lipoxygenase Activity	Protein Binding Unfolded Protein Binding
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Arachidonic Acid Metabolic Process Lipoxygenase Pathway Negative Regulation Of Cell Migration Prostate Gland Development Regulation Of Epithelial Cell Differentiation Positive Regulation Of Chemokine Production Lipid Oxidation Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Linoleic Acid Metabolic Process Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of Growth Hepoxilin Biosynthetic Process Endocannabinoid Signaling Pathway Cannabinoid Biosynthetic Process Lipoxin A4 Biosynthetic Process	Cellular Iron Ion Homeostasis Lysosomal Lumen Acidification Cellular Response To Increased Oxygen Levels Vacuolar Proton-transporting V-type ATPase Complex Assembly Lysosomal Protein Catabolic Process
Pathways		Synthesis of 15-eicosatetraenoic acid derivatives	RHOA GTPase cycle
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: CCDC115 CTAG1A CTAG1B KCNF1 PPARG RARA RXRA TRAIP TRIM21	10 interacting genes: ABI2 ALOX15B APP CSNK2B MIS18A NTAQ1 PLK1 PRKCZ RARS1 TK1
Entrez ID		247	84317
HPRD ID		04739	14428
Ensembl ID		ENSG00000179593	ENSG00000136710
Uniprot IDs		O15296	A1QKJ6 B8ZZ99 Q96NT0
PDB IDs		4NRE
Enriched GO Terms of Interacting Partners?
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