PCBD2 and IRF2BP1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		PCBD2	IRF2BP1
Description		pterin-4 alpha-carbinolamine dehydratase 2	interferon regulatory factor 2 binding protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cellular_component Nucleus	Nucleus Nucleoplasm
	Molecular Function	Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Identical Protein Binding	Transcription Corepressor Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Positive Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487) Height ( 28552196 18391951) Type 2 diabetes ( 24509480)	Apolipoprotein A1 levels ( 32203549) Asthma ( 31959851) Gallstone disease ( 30504769) HDL cholesterol levels ( 32203549) Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		41 interacting genes: AATF APP ASCC2 BCAS2 BRF1 C1D CDC5L CENPK CERS3 CHAF1A F2RL1 FBXO7 GTF2E1 GUCD1 HES4 IRF2BP1 KCNIP3 KLC3 LGALS14 MAGEA11 MAGEA6 MED21 MED30 MED4 MED7 MET MRFAP1 PBXIP1 PCBD1 PHF14 PML RUNX1T1 SNW1 SPG21 SSX3 SSX5 STAT3 TAL2 TGIF2LY XBP1 ZZZ3	8 interacting genes: ATF2 IRF2 IRF9 JDP2 PCBD2 SMAD1 TGIF1 UBE2L3
Entrez ID		84105	26145
HPRD ID		17824	17159
Ensembl ID		ENSG00000132570	ENSG00000170604
Uniprot IDs		Q9H0N5	Q8IU81
PDB IDs		4C45
Enriched GO Terms of Interacting Partners?
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