PLA2G6 and TRIM50

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PLA2G6	TRIM50
Description		phospholipase A2 group VI	tripartite motif containing 50
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Mitochondrion Cytosol Plasma Membrane Integral Component Of Membrane Pseudopodium Centriolar Satellite	Cytoplasm Cytosol
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Lysophospholipase Activity Phospholipase A2 Activity Protein Binding Calmodulin Binding Palmitoyl-CoA Hydrolase Activity Hydrolase Activity Serine Hydrolase Activity Protein Kinase Binding Identical Protein Binding ATP-dependent Protein Binding Calcium-independent Phospholipase A2 Activity Phosphatidyl Phospholipase B Activity Myristoyl-CoA Hydrolase Activity	Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Memory Urinary Bladder Smooth Muscle Contraction Antibacterial Humoral Response Cardiolipin Biosynthetic Process Phosphatidylcholine Catabolic Process Response To Endoplasmic Reticulum Stress Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cardiolipin Acyl-chain Remodeling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vasodilation Positive Regulation Of Exocytosis Phosphatidylethanolamine Catabolic Process Platelet Activating Factor Metabolic Process Phosphatidic Acid Metabolic Process Negative Regulation Of Synaptic Transmission, Glutamatergic Maternal Process Involved In Female Pregnancy Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Arachidonic Acid Secretion Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Ceramide Biosynthetic Process	Protein Ubiquitination
Pathways		Acyl chain remodelling of PC Acyl chain remodeling of CL Acyl chain remodelling of PE Role of phospholipids in phagocytosis COPI-independent Golgi-to-ER retrograde traffic	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Quinacrine
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Body fat percentage ( 26833246) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cutaneous nevi ( 21478494 19578365) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) Mammographic density (dense area) ( 25342443) Melanoma ( 21983787 28212542) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 32341527 30429480) Percent mammographic density ( 25342443) Platelet distribution width ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494) Triglyceride levels ( 32203549 28334899 32154731) Triglycerides ( 24097068 20686565)	Immune reponse to smallpox (secreted IL-12p40) ( 22610502)
Interacting Genes		12 interacting genes: CACNA1I CALM1 CCDC33 CEP76 MAT2B NUP93 RCBTB2 RUSC1 SERTAD2 TRIM50 USP54 ZBTB42	40 interacting genes: ARHGAP45 CDK18 CLK2 EFHC2 EPM2AIP1 FAM221B GCC1 HDAC6 IQUB KLHL2 L3MBTL2 LNX1 MEOX2 PIAS2 PLA2G6 RAD23A RSPH14 SNAI1 SPG21 SRC TEPSIN TRAF2 TRIM27 TSGA10IP TSSK3 UBASH3A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2N UBTD1 USP2 XAF1 ZNF438 ZNF620
Entrez ID		8398	135892
HPRD ID		04675	15566
Ensembl ID		ENSG00000184381	ENSG00000146755
Uniprot IDs		O60733	B7ZLG2 Q2M204 Q86XT4
PDB IDs
Enriched GO Terms of Interacting Partners?
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