F8A1 and DNMT3A

Number of citations of the paper that reports this interaction (PubMedID 19139273)
26

Data Source:
BioGRID (enzymatic study)

		F8A1	DNMT3A
Description		coagulation factor VIII associated 1	DNA methyltransferase 3 alpha
Image
GO Annotations	Cellular Component	Nucleus Early Endosome Nuclear Body	Chromosome, Centromeric Region Euchromatin Heterochromatin XY Body Nucleus Nucleoplasm Cytoplasm Nuclear Matrix
	Molecular Function	Molecular_function Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding Transcription Factor Binding Identical Protein Binding Metal Ion Binding Protein-cysteine Methyltransferase Activity
	Biological Process	Vesicle Cytoskeletal Trafficking Negative Regulation Of Proteasomal Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle DNA Methylation DNA Methylation-dependent Heterochromatin Assembly Regulation Of Gene Expression By Genetic Imprinting Spermatogenesis Aging Response To Xenobiotic Stimulus Response To Toxic Substance Response To Ionizing Radiation Response To Lead Ion Positive Regulation Of Cell Death Neuron Differentiation Response To Estradiol Response To Vitamin A Response To Cocaine DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Cellular Response To Amino Acid Stimulus Cellular Response To Ethanol Cellular Response To Hypoxia C-5 Methylation Of Cytosine Hepatocyte Apoptotic Process
Pathways			PRC2 methylates histones and DNA RMTs methylate histone arginines SUMOylation of DNA methylation proteins DNA methylation Defective pyroptosis
Drugs			Procaine Decitabine
Diseases
GWAS			Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Body shape index ( 34021172) Body size at age 10 ( 32376654) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Heel bone mineral density ( 30598549) Height ( 28552196 25282103 25429064 31562340 18391951) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Macular thickness ( 30535121) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494 27863252) Resistant hypertension ( 31545351) Type 1 diabetes ( 21980299) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: DNMT3A HTT MTNR1A SH3GLB1 SNTA1 TLR10	33 interacting genes: ALK CBX1 DDB1 DNMT1 DNMT3B DNMT3L EED EHMT1 EHMT2 EZH2 F8A1 H3C6 HDAC1 MDFI MEOX2 MYC NRIP1 PIAS1 PIAS2 PRMT5 PTGES3 SETDB1 SP100 SPI1 SUV39H1 TCL1A TERF2IP UBE2I UHRF1 USP7 ZBTB17 ZBTB18 ZNF513
Entrez ID		8263	1788
HPRD ID		02374	04141
Ensembl ID		ENSG00000288722	ENSG00000119772
Uniprot IDs		P23610	A0A0C4DG02 F8WE91 Q59HC6 Q9Y6K1
PDB IDs		6EZ8 6X9O	2QRV 3A1A 3A1B 3LLR 3SVM 4QBQ 4QBR 4QBS 4U7P 4U7T 5YX2 6BRR 6F57 6PA7 6W89 6W8B 6W8D 6W8J
Enriched GO Terms of Interacting Partners?
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