F8A1 and TLR10

Number of citations of the paper that reports this interaction (PubMedID 16482509)
22

Data Source:
HPRD (two hybrid)

		F8A1	TLR10
Description		coagulation factor VIII associated 1	toll like receptor 10
Image
GO Annotations	Cellular Component	Nucleus Early Endosome Nuclear Body	Plasma Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	Molecular_function Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	Vesicle Cytoskeletal Trafficking Negative Regulation Of Proteasomal Protein Catabolic Process	Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Toll-like Receptor 10 Signaling Pathway Innate Immune Response Positive Regulation Of Inflammatory Response
Pathways			Toll Like Receptor 10 (TLR10) Cascade IRAK4 deficiency (TLR5) MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Asthma ( 31361310 31959851 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Helicobacter pylori serologic status ( 23652523) Limited cutaneous systemic scleroderma ( 29293537) Self-reported allergy ( 23817569) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)
Interacting Genes		6 interacting genes: DNMT3A HTT MTNR1A SH3GLB1 SNTA1 TLR10	12 interacting genes: CAT ECH1 F8A1 FLNA FUT7 GLDC LUC7L3 MYD88 PTPN6 TLR1 TLR2 TRIM54
Entrez ID		8263	81793
HPRD ID		02374	05884
Ensembl ID		ENSG00000288722	ENSG00000174123
Uniprot IDs		P23610	A0A024R9W4 Q9BXR5
PDB IDs		6EZ8 6X9O	2J67
Enriched GO Terms of Interacting Partners?
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