DIAPH3 and NCKIPSD

Number of citations of the paper that reports this interaction (PubMedID 11509578)
29

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)

		DIAPH3	NCKIPSD
Description		diaphanous related formin 3	NCK interacting protein with SH3 domain
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytosol Intermediate Filament
	Molecular Function	Actin Binding Small GTPase Binding Cadherin Binding	Protein Binding Cytoskeletal Protein Binding Myosin Binding SH3 Domain Binding Arp2/3 Complex Binding
	Biological Process	Cytoskeleton Organization Actin Cytoskeleton Organization Actin Filament Polymerization	Endocytosis Cytoskeleton Organization Positive Regulation Of Neuron Projection Development
Pathways		RHO GTPases Activate Formins RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 27089180 34211149) Body mass index ( 28892062) Breast milk fatty acid composition (infant genotype effect) ( 29514873) Breast milk fatty acid composition (maternal genotype effect) ( 29514873) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Gut microbiota (functional units) ( 27694959) HOMA-B (corrected for HOMA-IR) ( 30369944) Metabolite levels ( 23823483) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) Number of sexual partners ( 30643258) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258)	Anorexia nervosa ( 31308545) Blood protein levels ( 28240269) Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Myocardial infarction ( 33532862) Parkinson's disease ( 28892059) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)
Interacting Genes		6 interacting genes: CDC42 NCKIPSD PDCD6 RAC1 RHOA SMAD9	42 interacting genes: ABI2 ARHGEF7 BAIAP2 CCDC187 CPNE2 CYSLTR2 DIAPH2 DIAPH3 DLG4 DMRTB1 ENKD1 FASLG GAS7 GRB2 HSPB1 ITGB1 KHDRBS1 LGALS4 MAPK3 MED25 NCK1 NCK2 PIN1 PKP2 POLR3C PRPF31 PSMD9 PSORS1C2 RBM22 RBP7 RXFP3 SHANK3 SNRPC SORBS3 STAC TSEN54 VEZF1 WAS WASL YWHAG ZBTB47 ZC2HC1C
Entrez ID		81624	51517
HPRD ID		10884	09450
Ensembl ID		ENSG00000139734	ENSG00000213672
Uniprot IDs		B4DPV3 Q9NSV4	Q9NZQ3
PDB IDs		5UWP 6X2Y	6DEC 6DED 6DEE
Enriched GO Terms of Interacting Partners?
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